The invention relates to a method for efficiently inducing pluripotent stem cells to be differentiated to retinal pigment epitheliums (RPE), and belongs to the biology technical field. By the adoption of the method, without adding any small molecule inducible stimulators, an in-vivo eyeball development process is simulated in vitro, and the pluripotent stem cells can be spontaneously differentiated into the RPEs. Compared with methods which have already been reported, no small molecule inducible stimulators are adopted, in-vivo eyeball development is strictly simulated, and thus a large number of RPEs differentiated from the pluripotent stem cells can be obtained simply, rapidly and efficiently.