The invention discloses a multi-angle vision locating laser marking machine and a laser marking method thereof. The multi-angle vision locating laser marking machine comprises a laser galvanometer scanning optical path module, a red light previewing module, a laser external coaxial device vision locating module, an Z-axis automatic focusing lifting table module and a theta 1 multi-angle rotating worktable module. The laser marking method includes three stages including a machine debugging stage, a product to-be-machined position locating learning stage and a laser marking stage. Under the requirement for the high yield, high-precision automatic laser marking processing of multiple work faces of a single product is rapidly achieved.