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发明公开
CN106966871A 一种五氟苯酚的制备方法 有权

一种五氟苯酚的制备方法
摘要：
本发明涉及一种五氟苯酚的制备方法，属于化合物合成领域。1所述方法包括下述工艺步骤：将五氟溴苯滴加到含有镁和碘的有机溶剂中得到格氏试剂；将所得格氏试剂滴加到‑20～30℃的硼酸酯B(OR)3的有机溶剂溶液中进行酯化反应；所得五氟苯硼酸的环戊基甲醚溶液与过氧化物在10～50℃反应，所述有机溶剂为环戊基甲醚或回收的环戊基甲醚。本发明仅使环戊基甲醚或回收的环戊基甲醚作为反应的溶剂，该溶剂利于精制回收，同时，本发明三步反应只用一种溶剂，溶剂品种单一，减少操作步骤，降低了生产成本。同时本发明所提供的方法原料易得、工艺稳定、操作方便、产品纯度高(≥99.5％)。
摘要（英）：

The invention relates to a preparation method for pentafluorophenol, and belongs to the technical field of the compound synthesis. The method comprises the following steps: adding Bromopentafluorobenzene to an organic solvent containing magnesium and iodine dropwise to obtain a Grignard reagent; adding the obtained Grignard reagent to the organic solvent solution of borate B(OR)3 in 20-30 DEG C dropwise, and performing the esterification reaction; enabling the obtained cyclopentyl methyl ether solution of the pentaflubenic acid to react with peroxide in 10-50 DEG C, wherein the organic solvent is the cyclopentyl methyl ether or the recycled cyclopentyl methyl ether. The preparation method is capable of using the cyclopentyl methyl ether or the recycled cyclopentyl methyl ether as the reactive solvent, and the solvent is good for the refined recycling. The provided method has the characteristics of easily obtained raw materials, stable technology, convenient operation and high product purity (greater than or equal to 99.5%).

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