The invention relates to a setting device associated with engine observation points and calibration parameters automatic searching. The engine observation points and calibration parameters definition module (1) is connected with the reading and loading module (3), used for writing the information of the engine observation points and calibration parameters and saving; the Package custom module (2) is connected with the reading and loading module (3), used for the custom of specific Package packages; the reading and loading module (3) is connected with the calibration parameters automatic searching and setting module (4) and the observation points setting module (5) respectively, used for reading the information of the observation points and calibration parameters and setting loading the corresponding attributes of the data object package ECU Type.mp of the observation points and the data object package ECU Type.parameter of the calibration parameters; and the calibration parameters automatic searching and setting module (4) is connected with the observation points setting module (5). The invention can automatically load the data and data information in the engine model, and has strong practicability.