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发明公开
CN107474017A 一种不对称烯丙基化反应合成手性N1-烯丙基嘧啶的方法 有权

一种不对称烯丙基化反应合成手性N1-烯丙基嘧啶的方法
摘要：
本发明公开了一种不对称烯丙基化反应合成手性N1-烯丙基嘧啶的方法，属于不对称合成领域。以N3-保护的嘧啶和烯丙基碳酸酯为原料，以[Rh(COD)Cl]2为催化剂，DTBM-Segphos或DTBM-MeOBIPHEP为手性配体，反应后得到手性N1-烯丙基嘧啶，收率中等至优秀。
摘要（英）：

The invention discloses a method for synthesizing chiral N1-allyl pyrimidine by asymmetric allyl reaction, and belongs to the field of asymmetric synthesizing. The method is characterized in that N3-protected pyrimidine and allyl carbonate are used as the raw materials, [Rh(COD)Cl]2 is used as a catalyst, DTBM-Segphos or DTBM-MeOBIPHEP is used as a chiral ligand, and the chiral N1-allyl pyrimidine is obtained after reaction, so that the yield rate is medium to excellent.

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