The invention discloses pyridotriazole compounds, a preparation method and application thereof. After long-term in-depth study, the inventor prepares a class of compounds A01-A20 with SMO target inhibitory activity, and the compounds belong to pyridotriazole compounds. Molecular docking tests indicate that the compounds provided by the invention can reach strong combination with the target protein SMO, also have an excellent inhibitory effect on various tumors, thus being expected to be used for preparation of SMO target inhibitors and antitumor drugs. The preparation method of the compounds provided by the invention has the characteristics of simple process and short time, greatly reduces the drug cost, and is suitable for large-scale production.