The invention discloses a PCB packaging device based on cooling technology. The PCB packaging device comprises an air outlet channel, a welding chamber and an air inlet channel which are successivelycommunicated. A clamping tool is arranged in a welding chamber and the clamping tool clamps a PCB board. An air-outlet fan, an air outlet filtering screen and a cleaning sheet are arranged inside theair outlet channel. The air outlet fan, the cleaning sheet and the air outlet filtering screen are arranged away from the PCB board from far to near. The air outlet filtering screen and the cleaning sheet adopt semiconductor refrigeration sheets, the cold surface and the hot surface of the air outlet filtering screen are arranged in parallel with a wind direction of the air outlet channel and thecold surface and the hot surface of the cleaning sheet are arranged in parallel with the wind direction of the air outlet channel. An air volume sensor is arranged on the air outlet filtering screen for detecting an air volume passing through the air outlet filtering screen. A control device is arranged on the outer wall of the air outlet channel. The air outlet filtering screen, the cleaning sheet and the air volume sensor are electrically connected to the control device. The PCB packaging device based on the cooling technology can effectively improve heat circulation efficiency through a mutual effect between the air outlet filtering screen and the cleaning sheet, can effectively improve heat circulation efficiency, can improve efficiency of a cooling system and can improve welding quality of the product.