The invention discloses an application of oyster peptides in preparing special medical application formula foods, and discloses a special medical application formula food suitable for 1-10-year-old people, a special medical application formula food suitable for 10-year-old or above people, and a preparation method of the two foods. The formula food comprises the following components: soybean protein isolate, whey proteins, oyster peptides, vegetable fat powder, maltodextrin, isomalt, fructo-oligosaccharides, inulin, a vitamin premix and a mineral premix. The special medical application formulafoods disclosed by the invention contain marine protein oyster peptides, and components and nutrients of products fully conform to relative national standards, fully meet the nutritional requirementsof the people aged 1-10 and over 10, and a preparation process is mature and facilitates industrialization.