The disclosure provides a method of manufacturing a non-aqueous electrolyte solution secondary battery and the non-aqueous electrolyte solution secondary battery. The manufacturing method includes: (A) preparing a first composite material by mixing a first positive electrode active material, a first conductive material and a first binder; (B) preparing a second composite material by mixing a second positive electrode active material, a second conductive material and a second binder; and (C) manufacturing a positive electrode by forming a positive electrode composite layer including the first composite material and the second composite material. The first positive electrode active material has an average discharge potential lower than that of the second positive electrode active material. The first conductive material has a first OAN with respect to 100 parts by weight of the first positive electrode active material. The second conductive material has a second OAN with respect to 100 parts by weight of the second positive electrode active material. A ratio of the second OAN to the first OAN is 1.3 or more and 2.1 or less. A sum of the first OAN and the second OAN is 31.64 ml/100 g or less.