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发明公开
CN108822089A 2-芳基咪唑烷类化合物、制备方法及其作为Hsp90抑制剂在抗肿瘤上的应用 无效 - 撤回

2-芳基咪唑烷类化合物、制备方法及其作为Hsp90抑制剂在抗肿瘤上的应用
摘要：
本发明属于医药技术领域，提供2-芳基咪唑烷类化合物、制备方法及其作为Hsp90抑制剂在抗肿瘤上的应用。本发明采用乙醇-水为溶剂，将化合物(II)、化合物(III)加入溶剂中，室温或者50～120℃搅拌反应3～12小时，通过TLC监测显示至化合物(III)原料全部转化后，通过抽滤和简单洗涤处理即可制得产物，化合物(II)、化合物(III)、化合物(I)依次为：本发明制备的2-芳基咪唑烷类化合物，体外抗乳腺癌细胞增殖活性检测表明，2-芳基咪唑烷类化合物具有较好的抗乳腺癌活性。
摘要（英）：

The invention belongs to the field of a medical technology and provides 2-arylimidazolidine compounds, a preparation method and application of the 2-arylimidazolidine compounds as Hsp90 inhibitors against tumors. The preparation method comprises the following steps: using ethanol-water as a solvent, adding a compound (II) and a compound (III) into the solvent, stirring and reacting at room temperature or at 50-120 DEG C for 3-12 h until it is displayed through TLC monitoring that all the raw materials of the compound (III) are converted, and carrying out suction filtration and simple washing treatment so as to prepare the product. The compound (III), the compound (II) and the compound (I) are successively as shown in the specification. It shows through in-vitro anti-breast cancer cell proliferation activity detection that the 2-arylimidazolidine compounds have good anti-breast cancer activity.

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