The invention discloses an error calibration method based on a Tip\Tilt mirror dynamic angle modulation interference system. The error calibration method includes the following steps that step one, the Tip\Tilt mirror dynamic angle modulation interference system is built; step two, space position and attitude of a Tip\Tilt mirror are adjusted, and an initial position is set; step three, a relationcurve between former 36 coefficients of Zernike and a deflection angle is drawn; step four, coefficient values of the former 36 coefficients of the Zernike in a tip/tilt mirror under different deflection directions and different deflection angles are obtained; and step five, by using results obtained in the step four, tip/tilt mirror output wavefront information of the system in an arbitrary deflection state is obtained, and thus calibration of system errors is achieved. The error calibration method based on the Tip\Tilt mirror dynamic angle modulation interference system has the advantages of dynamic, high efficiency and high universality.