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发明公开
CN109678944A 一种抗菌多肽HF-18及其制备方法和应用 有权

一种抗菌多肽HF-18及其制备方法和应用
摘要：
本发明公开了一种抗菌多肽HF-18及其制备方法和应用，该抗菌多肽HF-18的氨基酸序列如SEQ ID NO:1所示。本发明从八目鳗鱼多肽HFIAP-1出发，通过构效关系研究，获得α螺旋程度较好的18个氨基酸的多肽，并将其第12位的组氨酸替换为赖氨酸及第14位的甘氨酸替换为疏水性的苯丙氨酸，得到多肽HF-18(GFFKKAWRKVKKAFRRVL)。本发明制备所得的多肽HF-18，α螺旋程度和疏水性提高，合成成本降低，具有良好的体内外抗菌活性，可以应用于各种普通感染及顽固感染性疾病，作为现有抗生素的优良替代药物或辅助药物。
摘要（英）：

The invention discloses an anti-bacterial polypeptide HF-18 and a preparation method and application thereof. An amino acid sequence of the anti-bacterial polypeptide HF-18 is as shown in SEQ ID NO: 1. The preparation method comprises the following steps: initiating from a lamprey polypeptide HFIAP-1, researching a structure-activity relationship to acquire a 18-amino-acid polypeptide with a relatively good alpha-helix degree, and replacing histidine in a 12-th site by lysine and replacing glycine in a 14-th site by hydrophobic phenylalanine to obtain the polypeptide HF-18 (GFFKKAWRKVKKAFRRVL). The polypeptide HF-18 prepared by the invention is high in alpha-helix degree and hydrophobicity, low in synthetic cost, has good in vitro and vivo anti-bacterial activity, can be applied to variouscommon infection and stubborn infectious diseases, and can be used as a good alternative drug or auxiliary drug of current antibiotics.

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