The invention provides an indiscriminate and self-adaptive physiological control method based on a left ventricular assist device (LVAD). The indiscriminate and self-adaptive physiological control method includes: measuring the preload of the left ventricle to serve as the input value of a Frank-Starling like control system so as to generate the average pump flow reference value (Qpr) and pump flow pulse reference value (Qplusr) needed by a patient; using a Savitzky-Golay (S-G) filter, an expanded Kalman filter and a low-pass filter in a single processing module to perform noise elimination onextracted pump rotation speed signals, and estimating needed average pump flow measured value (Qp) and flow pulse measured value (Qplus) at the same time; inputting the Qpr, the Qplusr, the Qp and the Qplus into a PI controller to perform processing, and using output current signals to directly control the LVAD so as to achieve expected pump rotation speed.