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发明公开
CN110025789A 一种药物磷脂化合物及其药物组合物和应用 审中-实审

一种药物磷脂化合物及其药物组合物和应用
摘要：
本发明公开了一种药物磷脂化合物及其药物组合物和应用，该磷脂化合物为下列通式(1)的化合物或所述通式(1)的化合物与抗衡离子所形成的在药学上可接受的盐：式(1)中，m是2-10的正整数，n是5-10的正整数；X是药物；L是2-氨基乙基、2-三甲基胺基乙基阳离子。该药物组合物包括所述的药物磷脂化合物或所述的药物磷脂化合物与药效学上可接受的载体。所述药物磷脂化合物在制备抗肿瘤药物中的应用是将所述药物磷脂化合物或其在药学上可接受的盐，与药效学上可接受的载体制备成药剂。本发明的药物磷脂化合物及其脂质体纳米颗粒，可用作液体制剂、固体制剂、半固体制剂、灭菌制剂和无菌制剂，可在水相体系下形成脂质体。
摘要（英）：

The invention discloses a medical phospholipid compound and a medical composition and application thereof. The phospholipid compound is a compound as shown in the following general formula (1) or pharmaceutically acceptable salt prepared from the compound as shown in the general formula (1) and counterions; and in the formula (1), m is a positive integer from 2-10, n is a positive integer from 5-10, X is a medicine, and L is 2-aminoethyl cations and 2-trimethylamine ethyl cations. The medical composition comprises the medical phospholipid compound, or the medical phospholipid compound and a pharmaceutically acceptable carrier. The application of the medical phospholipid compound to preparation of antitumor medicines lies in that the medical phospholipid compound or the pharmaceutically acceptable salt thereof, and the pharmaceutically acceptable carrier are prepared into a medicament. The medical phospholipid compound and liposome nanometer particles thereof can be used as a liquid preparation, a solid preparation, a semisolid preparation, a sterilizing preparation and a sterile preparation, and liposomes can be formed under a water-phase system.

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