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发明公开
CN110064050A 含STn或F-STn的糖缀合物及其制备方法和在抗肿瘤疫苗中的应用 有权

含STn或F-STn的糖缀合物及其制备方法和在抗肿瘤疫苗中的应用
摘要：
本发明提供了含STn或F-STn的糖缀合物及其制备方法和在制备抗肿瘤疫苗中的应用，属于糖类缀合物技术领域。含STn或F-STn的糖缀合物，所述糖缀合物包括STn或F-STn和载体；所述STn或F-STn通过连接键与载体偶联；所述连接键包括酰胺键、肟键或C-N键；所述载体包括蛋白质、两性离子多糖、脂质或核酸。所述糖缀合物在制备抗肿瘤或癌症的疫苗或制备提高细胞和/或体液免疫应答的药物中的应用。F-STn的糖蛋白缀合物制备的疫苗能够提高体液免疫和细胞免疫应答，且产生的抗体能够有效地识别STn阳性肿瘤细胞，并且通过ADCC及CDC途径裂解STn阳性肿瘤细胞。
摘要（英）：

The invention provides a glycoconjugate containing STn or F-STn and a preparation method thereof and application for an anti-tumor vaccine, and belongs to the technical field of glycoconjugates. The glycoconjugate containing STn or F-STn comprises STn or F-STn and a vector; STn or F-STn is coupled to the vector through a connecting bond; the connecting bond includes an amido bond or an oxime bondor a C-N bond; the vector includes protein or zwitter-ion polysaccharide or lipid or nucleic acid. The glycoconjugate is applied to preparing an anti-tumor or anti-cancer vaccine or preparing a medicine for improving cell and/or humoral immune response. The vaccine prepared from the glycoconjugate of F-STn can improve humoral immunity and cellular immunologic response, the generated antibody can effectively recognize STn positive tumor cells, and the STn positive tumor cells can be cracked in an ADCC and CDC way.

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