The invention provides a vehicle lateral stability control method considering tire cornering stiffness changes. The vehicle lateral stability control method considering the tire cornering stiffness changes mainly comprises the following steps that a current yaw rate and side slip angle expected by a driver are calculated according to a vehicle-mounted sensor detection system and a two-degree-of-freedom vehicle model; and in the running process of a vehicle, the tire cornering stiffness is changed continuously and has uncertainty. According to the vehicle lateral stability control method considering the tire cornering stiffness changes, the tire load transfer amount and the current side slip angle magnitude are utilized to fit a specific value of the tire cornering stiffness, and change parameters of the tire cornering stiffness are added to a vehicle control model; tire side slip angle constraint conditions are introduced, a model predictive control algorithm is adopted, and the situation is finally described as an optimization constraint problem, and the current optimal control sequence is solved; and finally, the output of the control quantity is realized through an actuator, anda control objective of avoiding the tire lateral force saturation phenomenon is realized under the condition of considering the tire cornering stiffness changes.