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发明公开
CN110483639A 靶向AXL的抗体及抗体-药物偶联物及其制备方法和用途 无效 - 撤回

靶向AXL的抗体及抗体-药物偶联物及其制备方法和用途
摘要：
本发明公开了一种新的靶向AXL的单克隆抗体以及抗体-药物偶联物。本发明还公开了制备所述抗体、抗体-药物偶联物的方法。本发明的AXL抗体能够高效，高特异性地结合纯化的人AXL蛋白和多种肿瘤细胞表面的AXL，所述人源化抗体同样具有很高的亲和力及很低的免疫原性，所述AXL抗体-药物偶联物对AXL高表达的肿瘤细胞具有显著的抗肿瘤作用。
摘要（英）：

The invention discloses a novel monoclonal antibody targeting AXL and an antibody-drug conjugate. The invention further discloses a preparation method of the antibody and the antibody-drug conjugate.The AXL antibody can efficiently and highly specifically bind purified human AXL proteins and AXL on the surfaces of various tumor cells. The humanized antibody further has high affinity and low immunogenicity. The AXL antibody-drug conjugate has significant anti-tumor effects on tumor cells with high expression of AXL.

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