The invention discloses a hot-pressed sintering moulding method of large-size ceramic sputtering target material, which comprises the following steps: A) weighing powder raw material of target material; B) selecting moulds with the same diameter according to the need; C) putting moulds in the hot-pressed furnace; D) adopting vibrating hopper method to load material; measuring and guaranteeing the powder with the same piling height in the mould; E) heating to affix protective atmosphere; starting pressing machine; starting pressurizing; moving upper press head at 650-2100 deg.c under 15-40Mpa; insulating and keeping pressure for 20-60min until the relative density of target material reaches the designing value; F) adopting extra pressure maintaining technique to prepare the sintered blank of sputtered target material.