发明公开
EP0231537A2 Antigenic proteins and vaccines containing them for prevention of coccidiosis
失效
Antigene Proteine und diese enthaltende Impfstoffe zurVerhütungvon Kokzidiose。
- 专利标题： Antigenic proteins and vaccines containing them for prevention of coccidiosis
- 专利标题（中）： Antigene Proteine und diese enthaltende Impfstoffe zurVerhütungvon Kokzidiose。
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申请号： EP86202087.2申请日： 1986-11-24
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公开(公告)号： EP0231537A2公开(公告)日： 1987-08-12
- 发明人: Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
- 申请人： SOLVAY
- 申请人地址： Rue du Prince Albert, 33 B-1050 Bruxelles BE
- 专利权人： SOLVAY
- 当前专利权人： SOLVAY
- 当前专利权人地址： Rue du Prince Albert, 33 B-1050 Bruxelles BE
- 代理机构： Lechien, Monique
- 优先权： US805301 19851203; US805824 19851206; US807497 19851211; US808013 19851211
- 主分类号： C12N15/30
- IPC分类号： C12N15/30 ; C12N15/62 ; C12P21/00 ; A61K39/012
摘要：
Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix , Eimeria tenella or Eimeria maxima . One protein, useful for conferring protection against E. tenella and E. necatrix , has been derived from sporocysts of E. tenella . Other proteins, derived from merozoites of E. maxima , are useful for conferring protection against E. maxima .
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences including within these proteins are also provided.
Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences including within these proteins are also provided.
Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.
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