公开(公告)号：EP0453054A2

公开(公告)日：1991-10-23

申请号：EP91201751.4

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix and/or Eimeria tenella. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. necatrix.
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.

摘要翻译： 提供纯化的抗原蛋白质，其能够在鸡中诱导免疫应答，从而赋予针对艾美球虫和/或柔嫩艾美耳球虫感染的保护。 一种蛋白质可用于赋予对E. tenella和E. necatrix的保护作用，它来源于E. necatrix的孢子囊。 针对抗原蛋白的单克隆抗体也已经开发出来，可以用来赋予针对球虫病的鸡被动免疫。 还提供了编码抗原蛋白的核酸分子以及含有它们的表达载体。 还提供了用于产生具有包含在这些蛋白质内的氨基酸序列的蛋白质或抗原性多肽的方法。

公开(公告)号：EP0231537A2

公开(公告)日：1987-08-12

申请号：EP86202087.2

申请日：1986-11-24

申请人： SOLVAY

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K16/20 ,  A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix , Eimeria tenella or Eimeria maxima . One protein, useful for conferring protection against E. tenella and E. necatrix , has been derived from sporocysts of E. tenella . Other proteins, derived from merozoites of E. maxima , are useful for conferring protection against E. maxima .
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences including within these proteins are also provided.
Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.

摘要翻译： 具有确定的核酸序列和编码源自艾美球虫的抗原蛋白（I）的分离的基因组DNA分子是新的。 （I）具有分子量。 约25000道尔顿，由两个通过二硫键结合的多肽构成。 一种多肽具有分子量。 约17000道尔顿，具有封闭的N-末端氨基酸和限定的氨基酸序列。 另一种多肽具有分子量。 约8000道尔顿和一个确定的氨基酸序列。

公开(公告)号：EP0453054B1

公开(公告)日：1996-07-03

申请号：EP91201751.4

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

公开(公告)号：EP0231537B1

公开(公告)日：1992-03-11

申请号：EP86202087.2

申请日：1986-11-24

申请人： SOLVAY

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K16/20 ,  A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

公开(公告)号：EP0453054A3

公开(公告)日：1991-12-04

申请号：EP91201751.4

申请日：1986-11-24

申请人： SOLVAY (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/30 ,  C12N15/62 ,  C12P21/00 ,  A61K39/012

CPC分类号： C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix and/or Eimeria tenella. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. necatrix. Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis. Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.

公开(公告)号：EP0231537A3

公开(公告)日：1988-02-10

申请号：EP86202087

申请日：1986-11-24

申请人： SOLVAY & Cie (Société Anonyme)

发明人： Newman, Karel Z., Jr. ,  Gore, Thomas C. ,  Tedesco, John L. ,  Petersen, Gary R. ,  Brothers, Virginia M. ,  Files, James G. ,  Paul, Leland S. ,  Chang, Ray-Jen ,  Andrews, William H. ,  Kuhn, Irene ,  McCaman, Michael ,  Sias, Stacey R. ,  Nordgren, Robert M. ,  Dragon, Elizabeth A.

IPC分类号： C12N15/00 ,  C07H21/04 ,  C07H21/02 ,  C12N05/00 ,  C12N01/20 ,  C07K15/00 ,  C12P21/00 ,  A61K37/02 ,  A61K39/012 ,  C12R01/19

CPC分类号： C07K16/20 ,  A61K38/00 ,  A61K39/00 ,  C07K14/455 ,  C07K2319/00 ,  C07K2319/40 ,  C07K2319/61

摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix , Eimeria tenella or Eimeria maxima . One protein, useful for conferring protection against E. tenella and E. necatrix , has been derived from sporocysts of E. tenella . Other proteins, derived from merozoites of E. maxima , are useful for conferring protection against E. maxima . Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis. Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences including within these proteins are also provided. Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.