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1.发明授权Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by Eimeria tenella 失效抗真菌蛋白质和包含其抗体的疫苗及其保护性抗体，用于预防艾滋病毒感染引起的结核病
公开(公告)号：EP0164176B1
公开(公告)日：1992-09-09
申请号：EP85200889.5
申请日：1985-06-05
申请人： SOLVAY
发明人： Newman, Jr., Karel Z. , Tedesco, John L. , Simonson, Randy R. , Gore, Thomas C. , Petersen, Gary R. , Brothers, Virginia Mary , Files, James Gordon , Paul, Leland Shawn
IPC分类号： A61K39/012 , C12N15/00 , C07K13/00
CPC分类号： C07K16/425 , A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20
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2.发明公开Antigenic proteins and vaccines containing them for prevention of coccidiosis 失效Antigene Proteine und diese enthaltende Impfstoffe zurVerhütungvon Kokzidiose。
公开(公告)号：EP0231537A2
公开(公告)日：1987-08-12
申请号：EP86202087.2
申请日：1986-11-24
申请人： SOLVAY
发明人： Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
IPC分类号： C12N15/30 , C12N15/62 , C12P21/00 , A61K39/012
CPC分类号： C07K16/20 , A61K38/00 , A61K39/00 , C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix , Eimeria tenella or Eimeria maxima . One protein, useful for conferring protection against E. tenella and E. necatrix , has been derived from sporocysts of E. tenella . Other proteins, derived from merozoites of E. maxima , are useful for conferring protection against E. maxima .
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences including within these proteins are also provided.
Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.摘要翻译： 具有确定的核酸序列和编码源自艾美球虫的抗原蛋白（I）的分离的基因组DNA分子是新的。 （I）具有分子量。 约25000道尔顿，由两个通过二硫键结合的多肽构成。 一种多肽具有分子量。 约17000道尔顿，具有封闭的N-末端氨基酸和限定的氨基酸序列。 另一种多肽具有分子量。 约8000道尔顿和一个确定的氨基酸序列。
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3.发明公开
公开(公告)号：EP0453054A3
公开(公告)日：1991-12-04
申请号：EP91201751.4
申请日：1986-11-24
发明人： Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
IPC分类号： C12N15/30 , C12N15/62 , C12P21/00 , A61K39/012
CPC分类号： C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix and/or Eimeria tenella. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. necatrix. Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis. Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.
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4.发明公开
公开(公告)号：EP0231537A3
公开(公告)日：1988-02-10
申请号：EP86202087
申请日：1986-11-24
发明人： Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
IPC分类号： C12N15/00 , C07H21/04 , C07H21/02 , C12N05/00 , C12N01/20 , C07K15/00 , C12P21/00 , A61K37/02 , A61K39/012 , C12R01/19
CPC分类号： C07K16/20 , A61K38/00 , A61K39/00 , C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix , Eimeria tenella or Eimeria maxima . One protein, useful for conferring protection against E. tenella and E. necatrix , has been derived from sporocysts of E. tenella . Other proteins, derived from merozoites of E. maxima , are useful for conferring protection against E. maxima . Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis. Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences including within these proteins are also provided. Moreover, multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.
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5.发明公开
公开(公告)号：EP0453055A3
公开(公告)日：1991-11-06
申请号：EP91201752.2
申请日：1986-11-24
发明人： Newman, Karl Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Viriginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth B.
IPC分类号： A61K39/012 , C12N15/30 , C12N15/62 , C12P21/00
CPC分类号： C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
摘要： Multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.
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6.发明公开Antigenic proteins and vaccines containing them for prevention of coccidiosis 失效含有它们的抗原蛋白质和疫苗用于预防球虫病
公开(公告)号：EP0453054A2
公开(公告)日：1991-10-23
申请号：EP91201751.4
申请日：1986-11-24
发明人： Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
IPC分类号： C12N15/30 , C12N15/62 , C12P21/00 , A61K39/012
CPC分类号： C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
摘要： Purified antigenic proteins are provided which are capable of inducing in a chicken an immune response conferring protection against infection by Eimeria necatrix and/or Eimeria tenella. One protein, useful for conferring protection against E. tenella and E. necatrix, has been derived from sporocysts of E. necatrix.
Monoclonal antibodies directed against the antigenic proteins have also been developed which may be used to confer upon a chicken passive immunity against coccidiosis.
Further provided are nucleic acid molecules encoding the antigenic proteins as well as expression vectors containing them. Methods for producing the proteins or antigenic polypeptides having amino acid sequences included within these proteins are also provided.摘要翻译： 提供纯化的抗原蛋白质，其能够在鸡中诱导免疫应答，从而赋予针对艾美球虫和/或柔嫩艾美耳球虫感染的保护。 一种蛋白质可用于赋予对E. tenella和E. necatrix的保护作用，它来源于E. necatrix的孢子囊。 针对抗原蛋白的单克隆抗体也已经开发出来，可以用来赋予针对球虫病的鸡被动免疫。 还提供了编码抗原蛋白的核酸分子以及含有它们的表达载体。 还提供了用于产生具有包含在这些蛋白质内的氨基酸序列的蛋白质或抗原性多肽的方法。
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7.发明授权
公开(公告)号：EP0453054B1
公开(公告)日：1996-07-03
申请号：EP91201751.4
申请日：1986-11-24
发明人： Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
IPC分类号： C12N15/30 , C12N15/62 , C12P21/00 , A61K39/012
CPC分类号： C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
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8.发明授权
公开(公告)号：EP0231537B1
公开(公告)日：1992-03-11
申请号：EP86202087.2
申请日：1986-11-24
申请人： SOLVAY
发明人： Newman, Karel Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Virginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth A.
IPC分类号： C12N15/30 , C12N15/62 , C12P21/00 , A61K39/012
CPC分类号： C07K16/20 , A61K38/00 , A61K39/00 , C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
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9.发明公开
公开(公告)号：EP0453055A2
公开(公告)日：1991-10-23
申请号：EP91201752.2
申请日：1986-11-24
发明人： Newman, Karl Z., Jr. , Gore, Thomas C. , Tedesco, John L. , Petersen, Gary R. , Brothers, Viriginia M. , Files, James G. , Paul, Leland S. , Chang, Ray-Jen , Andrews, William H. , Kuhn, Irene , McCaman, Michael , Sias, Stacey R. , Nordgren, Robert M. , Dragon, Elizabeth B.
IPC分类号： A61K39/012 , C12N15/30 , C12N15/62 , C12P21/00
CPC分类号： C07K14/455 , C07K2319/00 , C07K2319/40 , C07K2319/61
摘要： Multi-component vaccines which comprises admixtures of Eimeria antigens or isotopes are disclosed.
摘要翻译： 包括艾美耳球虫抗原或同位素的外加剂多组分疫苗游离缺失盘。
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10.发明公开Antigenic proteins and vaccines containing them and protective antibodies directed to them for prevention of coccidiosis caused by Eimeria tenella and Eimeria necatrix 失效抗生素蛋白质和包含它们的疫苗和保护性抗体，用于预防艾米利亚·泰尼拉和艾美豹NECATRIX引起的预防结核病
公开(公告)号：EP0164176A3
公开(公告)日：1987-05-27
申请号：EP85200889
申请日：1985-06-05
发明人： Newman, Jr., Karel Z. , Tedesco, John L. , Simonson, Randy R. , Gore, Thomas C. , Petersen, Gary R. , Brothers, Virginia Mary , Files, James Gordon , Paul, Leland Shawn
IPC分类号： A61K39/012 , C12N15/00 , C12P21/00 , A61K39/395
CPC分类号： C07K16/425 , A61K38/00 , A61K39/00 , C07K14/455 , C07K16/20
摘要： A purified antigenic protein has been obtained which is capable of inducing in a chicken an immune response conferring protection against infection by Eimeria tenella or Eimeria necatrix. The protein has a molecular weight of about 25,000 and is composed of two polypeptides joined by a disulfide bond. The two polypeptide subunits have molecular weights of about 17,000 and about 8,000, respectively. The gene encoding the protein has been sequenced and the amino acid sequence of the protein deduced therefrom and by direct peptide sequencing. The protein and antigenic polypeptides having an amino acid sequence included within the protein may be incorporated into a vaccine for conferring upon a chicken active immunity against infection by E. tenella and E. necatrix. A hybridoma cell line (ATCC No. HB8561) has been developed which produces a monoclonal antibody designated Ptn 7.2A4/4. This antibody may be used to confer upon a chicken specific passive protection against infection by E. tenella and E. necatrix. The antibody may also be used to obtain the purified protein antigen and the 11,500 and 6,500 dalton polypeptide fragments thereof. Finally, an anti-idiotype antibody to the Ptn. 7.2A4/4 monoclonal antibody may be prepared and used to confer upon a chicken active immunity against E. tenella and E. necatrix infection. Legend * Initial amino acid of 17.000 dalton peptide ** Pinal amino acid of 17.000 dalton peptide + Initial amino acid of 8,000 dalton peptide ++ Pinal amino acid of 8,000 dalton peptide Key to ambiguous bases 3= Probably C 5 Probably A 7 Maybe C 8 Maybe T 0 Maybe C Y C or T M = C or G
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