发明公开
EP0561194A2 Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
失效
抗Felincalicivirus rekombinanterAntikörperunddafürkodierendes Gen。
- 专利标题: Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
- 专利标题(中): 抗Felincalicivirus rekombinanterAntikörperunddafürkodierendes Gen。
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申请号: EP93103066.2申请日: 1993-02-26
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公开(公告)号: EP0561194A2公开(公告)日: 1993-09-22
- 发明人: Kimachi, Kazuhiko , Maeda, Hiroaki , Nishiyama, Kiyoto , Tokiyoshi, Sachio , Tohya, Yukinobu, c/o Agriculture Department , Mikami, Takeshi
- 申请人: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 申请人地址: 668, Ohkubo Shimizu-machi Kumamoto-shi Kumamoto-ken JP
- 专利权人: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
- 当前专利权人地址: 668, Ohkubo Shimizu-machi Kumamoto-shi Kumamoto-ken JP
- 代理机构: Vossius, Volker, Dr.
- 优先权: JP79189/92 19920228
- 主分类号: C12N15/13
- IPC分类号: C12N15/13 ; C12P21/08 ; C07K13/00 ; A61K39/125 ; C12N15/62
摘要:
Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line lD7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.
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