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公开(公告)号：EP0179483A3
公开(公告)日：1989-03-01
申请号：EP85113585.5
申请日：1985-10-25
IPC分类号： C12P21/08
CPC分类号： C07K16/082
摘要： Disclosed are monoclonal antibodies to the HBsAg which are prepared by forming hybridomas between human peripheral blood lymphocyte cells, derived from humans having high titers of anti-HBsAg antibodies, and myeloma cells, cloning the hybridomas and selecting the antibody-producing clones. The monoclonal antibodies react with all the subtypes of the HBsAg and are very effective in diagnosis and treatment of diseases due to the viral infection.
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公开(公告)号：EP0179483B1
公开(公告)日：1991-12-11
申请号：EP85113585.5
申请日：1985-10-25
IPC分类号： C12P21/08
CPC分类号： C07K16/082
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公开(公告)号：EP0179483A2
公开(公告)日：1986-04-30
申请号：EP85113585.5
申请日：1985-10-25
IPC分类号： C12P21/08
CPC分类号： C07K16/082
摘要： Disclosed are monoclonal antibodies to the HBsAg which are prepared by forming hybridomas between human peripheral blood lymphocyte cells, derived from humans having high titers of anti-HBsAg antibodies, and myeloma cells, cloning the hybridomas and selecting the antibody-producing clones. The monoclonal antibodies react with all the subtypes of the HBsAg and are very effective in diagnosis and treatment of diseases due to the viral infection.
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4.发明公开Anti-feline calicivirus recombinant antibody and gene fragment encoding the same 失效抗体药代动物抗体和编码其的基因片段
公开(公告)号：EP0561194A3
公开(公告)日：1994-08-24
申请号：EP93103066.2
申请日：1993-02-26
发明人： Kimachi, Kazuhiko , Maeda, Hiroaki , Nishiyama, Kiyoto , Tokiyoshi, Sachio , Tohya, Yukinobu, c/o Agriculture Department , Mikami, Takeshi
IPC分类号： C12N15/13 , C12P21/08 , C07K13/00 , A61K39/125 , C12N15/62
CPC分类号： C07K16/1045 , A61K38/00
摘要： Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line lD7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.
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5.发明授权Anti-feline calicivirus recombinant antibody and gene fragment encoding the same 失效抗Felincalicivirus重组抗体和基因编码相同
公开(公告)号：EP0561194B1
公开(公告)日：2000-06-07
申请号：EP93103066.2
申请日：1993-02-26
发明人： Kimachi, Kazuhiko , Maeda, Hiroaki , Nishiyama, Kiyoto , Tokiyoshi, Sachio , Tohya, Yukinobu, c/o Agriculture Department , Mikami, Takeshi
IPC分类号： C12N15/13 , C12P21/08 , C07K14/00 , A61K39/125 , C12N15/62
CPC分类号： C07K16/1045 , A61K38/00
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6.发明公开Anti-feline calicivirus recombinant antibody and gene fragment encoding the same 失效抗Felincalicivirus rekombinanterAntikörperunddafürkodierendes Gen。
公开(公告)号：EP0561194A2
公开(公告)日：1993-09-22
申请号：EP93103066.2
申请日：1993-02-26
发明人： Kimachi, Kazuhiko , Maeda, Hiroaki , Nishiyama, Kiyoto , Tokiyoshi, Sachio , Tohya, Yukinobu, c/o Agriculture Department , Mikami, Takeshi
IPC分类号： C12N15/13 , C12P21/08 , C07K13/00 , A61K39/125 , C12N15/62
CPC分类号： C07K16/1045 , A61K38/00
摘要： Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line lD7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.
摘要翻译： 提供了有效治疗，预防和诊断FCV感染的抗FCV（猫杯状病毒）猫科型重组抗体和用于制备所述抗体的基因片段。 构建能够产生具有优异的FCV中和活性的小鼠单克隆抗体的细胞系1D7，获得编码负责所述抗体的FCV特异性结合的V区的基因片段。 该基因片段和编码猫抗体恒定区的基因用于产生嵌合抗FCV重组抗体。 获得的重组抗体是一种新的抗体，可用于诊断，治疗和预防猫病毒感染，特别是猫杯状病毒感染，对猫的施用具有高度的安全性。
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