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    Anti-feline calicivirus recombinant antibody and gene fragment encoding the same
    3.
    发明公开
    Anti-feline calicivirus recombinant antibody and gene fragment encoding the same 失效
    抗Felincalicivirus rekombinanterAntikörperunddafürkodierendes Gen。

    公开(公告)号：EP0561194A2

    公开(公告)日：1993-09-22

    申请号：EP93103066.2

    申请日：1993-02-26

    申请人： Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

    发明人： Kimachi, Kazuhiko ,  Maeda, Hiroaki ,  Nishiyama, Kiyoto ,  Tokiyoshi, Sachio ,  Tohya, Yukinobu, c/o Agriculture Department ,  Mikami, Takeshi

    IPC分类号： C12N15/13 ,  C12P21/08 ,  C07K13/00 ,  A61K39/125 ,  C12N15/62

    CPC分类号： C07K16/1045 ,  A61K38/00

    摘要： Anti-FCV (feline calicivirus) feline-type recombinant antibody effective for treatment, prevention and diagnosis of FCV infection and a gene fragment useful for preparation of said antibody are provided. Cell line lD7 capable of producing a mouse monoclonal antibody having an excellent FCV-neutralizing activity was constructed and a gene fragment coding for the V region in charge of the FCV-specific binding of said antibody was obtained. This gene fragment and the gene coding for the constant region of the feline antibody are used to give a chimeric anti-FCV recombinant antibody. The obtained recombinant antibody is a novel antibody and is useful for the diagnosis, treatment and prevention of feline virus infections, particularly feline calicivirus infection, with high safety in administration into cats.

    摘要翻译： 提供了有效治疗，预防和诊断FCV感染的抗FCV（猫杯状病毒）猫科型重组抗体和用于制备所述抗体的基因片段。 构建能够产生具有优异的FCV中和活性的小鼠单克隆抗体的细胞系1D7，获得编码负责所述抗体的FCV特异性结合的V区的基因片段。 该基因片段和编码猫抗体恒定区的基因用于产生嵌合抗FCV重组抗体。 获得的重组抗体是一种新的抗体，可用于诊断，治疗和预防猫病毒感染，特别是猫杯状病毒感染，对猫的施用具有高度的安全性。