发明公开
- 专利标题： (1'R,3S,4R)4-acylthio azetidinones
- 专利标题（中）： （1'R，3S，4R）4-酰硫基氮杂环丁酮
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申请号： EP93109103.7申请日： 1993-06-07
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公开(公告)号： EP0574784A1公开(公告)日： 1993-12-22
- 发明人: Cabri, Walter , Candiani, Ilaria , Bedeschi, Angelo , Zarini, Franco
- 申请人： PHARMACIA S.p.A.
- 申请人地址： Via Robert Koch, 1.2 I-20152 Milano IT
- 专利权人： PHARMACIA S.p.A.
- 当前专利权人： PHARMACIA S.p.A.
- 当前专利权人地址： Via Robert Koch, 1.2 I-20152 Milano IT
- 代理机构： Giambrocono, Alfonso, Dr. Ing.
- 优先权： GB9212707 19920616; GB9226292 19921217
- 主分类号： C07D205/09
- IPC分类号： C07D205/09 ; C07F7/18 ; C07D401/12 ; C07D405/12 ; C07D499/88
摘要：
There is provided a process for preparing a compound of formula (I)
wherein R is H or a hydroxy protecting group, R₂ is an organic residue and R₃ is H or a nitrogen protecting group, which process comprises reacting together a compound of formula (II)
wherein R₁ is a C₁-C₄ alkyl or a phenyl group, R and R₃ are as defined above, a compound of formula (III)
wherein R₂ is as defined above
and X is a cation or a silicon-containing residue, and a salt of a group IIa, IIb or transition element. The compounds of formula (I) are intermediates in the synthesis of penem antibiotics.
wherein R is H or a hydroxy protecting group, R₂ is an organic residue and R₃ is H or a nitrogen protecting group, which process comprises reacting together a compound of formula (II)
wherein R₁ is a C₁-C₄ alkyl or a phenyl group, R and R₃ are as defined above, a compound of formula (III)
wherein R₂ is as defined above
and X is a cation or a silicon-containing residue, and a salt of a group IIa, IIb or transition element. The compounds of formula (I) are intermediates in the synthesis of penem antibiotics.
公开/授权文献
- EP0574784B1 Process for preparing (1'R,3S,4R)4-acylthio azetidinones 公开/授权日：2001-12-05
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