PCT No.PCT / EP92 / 02653 Sec。 371日期：1994年5月27日 102（e）日期1994年5月27日PCT提交1992年11月19日PCT公布。 公开号WO93 / 11105 日本6月10日，1993.Leukotriene-B4衍生物式Ⅰ（Ⅰ）它们与生理上相容的碱和它们的环糊精包合物的盐被描述。

Leukotriene-B4 derivatives of the formula (I), wherein R1 is CH2OH, CH3, CF3, COOR5, CONR6R7, or R1 with R2 a carbonyl group; R2 and R3 are identical or different and denote H or an organic acid residue having 1 to 15 carbon atoms; R4 denotes H, C1-C10 alkyl, optionally substituted one or more times by chlorine or bromine, C3-C10 cycloalkyl, a C6-C10 aryl radical optionally substituted independently of one another one or more times by chlorine, bromine, phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxyl or hydroxyl group, or an aromatic heterocyclic 5- or 6-membered ring having at least 1 heteroatom; R5 is hydrogen, C1-C10 alkyl, C3-C10 cycloalkyl, C6-C10 aryl residue optionally substituted by 1-3 chlorine, bromine, phenyl, C1-C4 alkyl, C1-C4 alkoxy, fluoromethyl, chloromethyl, trifluoromethyl, carboxy or hydroxy aryl CH2CO- (C6-C10) or a 5- or 6-membered ring having at least one heteroatom; A represents a tetramethylene group, trans, trans-CH = CH-CH = CH-, or -CH2CH2-CH = CH-; B denotes an alkylene group of C1 to C10 straight or branched chain, optionally substituted by fluorine, or the group (a); D denotes a direct bond, oxygen, sulfur, -C? C-, -CH = CR8 or may represent a direct bond with B; R6 and R7 are identical or different and are H or C1-C4 alkyl, or R7 is H and R6 is C1-C10 alkanoyl or alcansulfonyle C1-C10; R8 is H, C1-C5, chlorine, bromine; m denotes the numbers 1 or 4 and n is between 3 and 5. The invention also relates to the salts thereof with physiologically tolerable bases when R 5 denotes hydrogen, and their cyclodextrin clathrates.