Invention Publication
- Patent Title: NEUE LEUKOTRIEN-B 4?-ANTAGONISTEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
- Patent Title (English): New leukotriene-b4 antagonists, process for preparing the same and their use as medicaments
- Patent Title (中): 新白三烯B 4?拮抗剂,生产与应用,药物的方法。
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Application No.: EP93919109.0Application Date: 1993-08-19
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Publication No.: EP0656896A1Publication Date: 1995-06-14
- Inventor: BUCHMANN, Bernd , SKUBALLA, Werner , HEINDL, Josef , FRÖHLICH, Wolfgang , EKERDT, Roland , GIESEN, Claudia
- Applicant: SCHERING AKTIENGESELLSCHAFT
- Applicant Address: D-13342 Berlin DE
- Assignee: SCHERING AKTIENGESELLSCHAFT
- Current Assignee: SCHERING AKTIENGESELLSCHAFT
- Current Assignee Address: D-13342 Berlin DE
- Priority: DE19924228201 19920825
- International Announcement: WO1994004522 19940303
- Main IPC: C07D213
- IPC: C07D213 ; C07C51 ; C07C59 ; C07C65 ; C07C67 ; C07C69 ; C07C235 ; C07D317
Abstract:
Antagonists of the leukotrienes-B4 have formula (I), in which n is an integer between 2 and 5, X is a direct bond, 1 to 6 methylene units, an ortho-, meta- or para-substituted phenyl ring or a meta- or para-substituted pyridin ring; Y is a bond to a hydrogen atom and at the same time to a hydroxy group, an oxygen atom with a double bond or -O-CH2-CH2-O-; R1 and R2 stand for the rest OH, -O-(C1-C4)-alkyl, O-(C3-C6)-cycloalkyl, -O-(C6-C10)-aryl, -O-(C7-C12)-aralkyl, O-(CH2)-CO-(C6-C10)-aryl or the residue NHR3, in which R3 stands for hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl or (C7-C12)-aralkyl. Also disclosed are the salts of said antagonists with physiologically tolerable bases and their cyclodextrin clathrates.
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