Invention Grant
EP0656896B1 NEUE LEUKOTRIEN-B4-ANTAGONISTEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
失效
新白三烯B4拮抗剂，其制造方法相同，它们作为药物
- Patent Title: NEUE LEUKOTRIEN-B4-ANTAGONISTEN, VERFAHREN ZU IHRER HERSTELLUNG UND IHRE VERWENDUNG ALS ARZNEIMITTEL
- Patent Title (English): New leukotriene-b4 antagonists, process for preparing the same and their use as medicaments
- Patent Title (中): 新白三烯B4拮抗剂，其制造方法相同，它们作为药物
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Application No.: EP93919109.4Application Date: 1993-08-19
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Publication No.: EP0656896B1Publication Date: 1997-12-17
- Inventor: BUCHMANN, Bernd , SKUBALLA, Werner , HEINDL, Josef , FRÖHLICH, Wolfgang , EKERDT, Roland , GIESEN, Claudia
- Applicant: SCHERING AKTIENGESELLSCHAFT
- Applicant Address: 13342 Berlin DE
- Assignee: SCHERING AKTIENGESELLSCHAFT
- Current Assignee: SCHERING AKTIENGESELLSCHAFT
- Current Assignee Address: 13342 Berlin DE
- Priority: DE4228201 19920825
- International Announcement: WO9404522 19940303
- Main IPC: C07D317/22
- IPC: C07D317/22 ; C07C69/736 ; C07D405/12 ; C07C59/68 ; C07C59/90 ; A61K31/335
Abstract:
Antagonists of the leukotrienes-B4 have formula (I), in which n is an integer between 2 and 5, X is a direct bond, 1 to 6 methylene units, an ortho-, meta- or para-substituted phenyl ring or a meta- or para-substituted pyridin ring; Y is a bond to a hydrogen atom and at the same time to a hydroxy group, an oxygen atom with a double bond or -O-CH2-CH2-O-; R1 and R2 stand for the rest OH, -O-(C1-C4)-alkyl, O-(C3-C6)-cycloalkyl, -O-(C6-C10)-aryl, -O-(C7-C12)-aralkyl, O-(CH2)-CO-(C6-C10)-aryl or the residue NHR3, in which R3 stands for hydrogen, (C1-C4)-alkyl, (C3-C6)-cycloalkyl or (C7-C12)-aralkyl. Also disclosed are the salts of said antagonists with physiologically tolerable bases and their cyclodextrin clathrates.
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