发明公开
EP0673252A1 ADMINISTRATION OF OLIGONUCLEOTIDES ANTISENSE TO DOPAMINE RECEPTOR MRNA FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL PATHOLOGIES
失效
多巴胺受体mRNA反SENSEN寡核苷酸的神经系统病变的诊断和治疗。
- 专利标题： ADMINISTRATION OF OLIGONUCLEOTIDES ANTISENSE TO DOPAMINE RECEPTOR MRNA FOR DIAGNOSIS AND TREATMENT OF NEUROLOGICAL PATHOLOGIES
- 专利标题（中）： 多巴胺受体mRNA反SENSEN寡核苷酸的神经系统病变的诊断和治疗。
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申请号： EP94904446.0申请日： 1993-12-14
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公开(公告)号： EP0673252A1公开(公告)日： 1995-09-27
- 发明人: WEISS, Benjamin
- 申请人： START TECHNOLOGY PARTNERSHIP
- 申请人地址： 2200 Renaissance Boulevard, Suite 250 Gulph Mills, PA 19406 US
- 专利权人： START TECHNOLOGY PARTNERSHIP
- 当前专利权人： START TECHNOLOGY PARTNERSHIP
- 当前专利权人地址： 2200 Renaissance Boulevard, Suite 250 Gulph Mills, PA 19406 US
- 代理机构： Baldock, Sharon Claire, et al
- 优先权： US19920991582 19921214
- 国际公布： WO1994013303 19940623
- 主分类号： G01N33
- IPC分类号： G01N33 ; A61K31 ; A61P25 ; C07H21 ; C12N15 ; C12Q1
摘要：
A method and pharmaceutical preparation are provided for diagnosing and treating pathological conditions related to a dopamine receptor abnormality. The method comprises administering to a patient having such a pathological condition an oligonucleotide antisense to one or more RNA molecules encoding one of the several dopamine receptors. The antisense oligonucleotides bind specifically to expression-controlling sequences of such RNA molecules, thereby selectively controlling expression of one or more dopamine receptor subtypes, and alleviating the pathological conditions related to their expression.
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