The invention relates to Pyridopyrimidones, Quinolines and fused N-heterocyclic compounds of formula (I) wherein Z is a group of the formula (a) or (b) in which X1 is N or C-R1, X2 is N or C-R9, X3 is N or C-R2, R1 is lower alkyl, R2 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, R3 is halogen, etc., R4 is halogen, etc., R5 is a group of formula (c), etc., A is lower alkylene, and Y is O, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.