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1.发明授权QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS 失效喹啉，其制造方法相同，它们作为药物
公开(公告)号：EP0900203B1
公开(公告)日：2003-03-19
申请号：EP97919665.6
申请日：1997-04-24
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D215/26 , C07D401/04 , C07D401/14 , C07D401/12 , A61K31/47
CPC分类号： C07D231/12 , C07D215/26 , C07D215/42 , C07D233/56 , C07D249/08 , C07D401/12
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2.发明公开QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS 失效喹啉，用于生产及其作为coorperation
公开(公告)号：EP0900203A1
公开(公告)日：1999-03-10
申请号：EP97919665.0
申请日：1997-04-24
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
CPC分类号： C07D231/12 , C07D215/26 , C07D215/42 , C07D233/56 , C07D249/08 , C07D401/12
摘要： This invention relates to a compound of formula (I) wherein R1 is lower alkyl, R2 is heterocyclic group, etc., R3 is hydrogen, lower alkyl or halogen, R4 is lower alkyl or halogen, R5 is amino substituted with substituent(s) selected from the group consisting of lower alkyl and acyl, etc., and A is lower alkylene, and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human beings or animals.
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公开(公告)号：EP1000932B1
公开(公告)日：2004-09-15
申请号：EP98929724.7
申请日：1998-06-26
发明人： YAMASAKI, Noritsugu , IMOTO, Takafumi , HIRAMURA, Takahiro , ONOMURA, Osamu , NISHIKAWA, Masahiro , KAYAKIRI, Hiroshi , ABE, Yoshito , HAMASHIMA, Hitoshi , SAWADA, Hitoshi
IPC分类号： C07C311/51 , C07D233/64 , C07D233/68 , C07D213/56 , C07D409/12 , A61K31/18 , A61K31/415 , A61K31/44
CPC分类号： C07D213/78 , C07C311/51 , C07D213/81 , C07D233/64 , C07D233/68 , C07D409/06
摘要： Novel aromatic ring derivatives represented by general formula (I) or pharmaceutically acceptable salts thereof. Because of having hypoglycemic and PDE 5 inhibitory activities, these compounds and salts thereof are useful as remedies for impaired glucose tolerance, diabetes, complication of diabetes, insulin-resistant syndrome, polycystic ovary syndrome, hyperlipidemia, atherosclerosis, cardio-vascular diseases, hyperglycemia, hypertension, angina pectoris, pulmonary hypertension, congestive heart failure, glomerular diseases, tubular interstitial diseases, renal insufficiency, atherosclerosis, angiostenosis, peripheral vascular diseases, cerebral stroke, chronic reversible obstructive diseases, autoimmune diseases, allergic rhinitis, urticaria, glaucoma, diseases characterized by disordered intestinal motion, sexual impotence, nephritis, cachexia, pancreatitis, post-PTCA reconstriction, etc. In said formula (I), Nu represents a 5- or 6-membered aromatic ring; ch1 and ch2 represent each a cross-linking group; and A represents an aromatic ring.
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4.发明公开SULFONAMIDE COMPOUNDS AND USES THEREOF AS MEDICINES 审中-公开SUVFONAMID-DERIVATE UND ANWENDUNGEN DAVON ALS MEDIKAMENTE
公开(公告)号：EP1136492A1
公开(公告)日：2001-09-26
申请号：EP99973290.2
申请日：1999-12-01
发明人： KAYAKIRI, Hiroshi , ABE, Yoshito , HAMASHIMA, Hitoshi , SAWADA, Hitoshi , ISHIBASHI, Naoki , SETOI, Hiroyuki , OKU, Teruo , YAMASAKI, Noritsugu , IMOTO, Takafumi , HIRAMURA, Takahiro
IPC分类号： C07D471/04 , A61K31/437 , A61P43/00 , A61P3/06 , A61P3/10 , A61P9/08 , A61P11/08 , A61P37/08
CPC分类号： C07D471/04
摘要： The present invention relates to a sulfonamide compound of the formula (I):
wherein each symbol is as defined in the specification, a salt thereof, and a pharmaceutical composition containing same. This compound can be an effective agent for the prophylaxis and treatment of the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy suppressing action.摘要翻译： 本发明涉及式（I）的磺酰胺化合物：其中各符号如说明书中所定义，其盐，和含有它的药物组合物。 该化合物可以是用于预防和治疗基于降血糖作用的可治疗疾病的有效药物，以及基于cGMP-PDE抑制作用，平滑肌松弛作用，支气管扩张作用，血管舒张作用， 平滑肌细胞抑制作用和过敏抑制作用。
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公开(公告)号：EP0774462A1
公开(公告)日：1997-05-21
申请号：EP95926025.8
申请日：1995-07-25
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D235/06 , C07D235/26 , C07D263/56 , C07D263/58 , C07D277/66 , C07D277/68 , C07D277/70 , C07D307/79
CPC分类号： C07D209/48 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/26 , C07D235/28 , C07D235/30 , C07D263/56 , C07D277/64 , C07D307/79 , C07D307/80 , C07D307/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07F7/1856
摘要： This invention relates to a heterocyclic compound of the formula :
wherein
a group of the formula : is a group of the formula :
etc.,
X is O, S or N-R 5 ,
R 1 is lower alkyl, etc.,
R 5 is hydrogen, lower alkyl, etc.,
R 2 is hydrogen, halogen, lower alkyl, etc.,
R 3 is halogen, lower alkyl, etc.,
R 4 is amino optionally having suitable substituent(s),
and
A is lower alkylene,
and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.摘要翻译： 本发明涉及下式的杂环化合物：其中下列基团为：下式基团：CHEM等，X为O，S或NR 5，R 1， 是低级烷基等，R 5是氢，低级烷基等，R 2是氢，卤素，低级烷基等，R 3是卤素，低级烷基等， 4>是任选具有合适取代基的氨基，A是低级亚烷基及其盐，其制备方法，以及包含其的用于预防和/或治疗缓激肽或其类似物的药物组合物 介导人类或动物的疾病。
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6.发明授权
公开(公告)号：EP0807105B1
公开(公告)日：2004-06-16
申请号：EP95935563.7
申请日：1995-10-25
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D215/16 , A61K31/47 , C07D471/02 , A61K31/395 , C07D215/26 , C07D471/04
CPC分类号： C07D401/12 , C07D215/26 , C07D215/40 , C07D215/42 , C07D215/48 , C07D241/40 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
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公开(公告)号：EP1142880A1
公开(公告)日：2001-10-10
申请号：EP99961320.1
申请日：1999-12-22
发明人： YAMASAKI, Noritsugu , IMOTO, Takafumi , HIRAMURA, Takahiro , KAWAUCHI, Miho , OKU, Teruo , KAYAKIRI, Hiroshi , SAWADA, Hitoshi , ABE, Yoshito , HAMASHIMA, Hitoshi , ISHIBASHI, Naoki , SETOI, Hiroyuki
IPC分类号： C07D235/08 , C07D405/10 , C07D409/10 , C07D409/12 , A61K31/4184 , A61K31/5377 , A61P3/06 , A61P3/10 , A61P9/10 , A61P15/10 , A61P27/06 , A61P9/00
CPC分类号： C07D405/10 , C07D235/08 , C07D235/12 , C07D405/12 , C07D409/10 , C07D409/12 , C07D409/14
摘要： The present invention provides novel benzimidazole derivatives of the following formula (I) and salts thereof:
wherein R 1 represents a lower alkyl group or a lower alkyloxy-lower alkyl group: R 2 represents a hydrogen atom, a halogen atom, an alkyl group having 1 to 8 carbon atoms, an aryl group, and such; R 3 represents a lower alkyl group, a lower alkenyl group, an aryl group, a lower alkylaryl group, an aryl-lower alkenyl group, a halothienyl group, a lower alkylamino group, or an aryl-lower alkylamino group; A represents a benzene ring, a naphthalene ring, or a pyridine ring; and X represents a halogen atom. The derivatives and their salts have blood sugar level-depressing activity or PDE5-inhibiting activity, and are useful as pharmaceutical preparations.摘要翻译： 本发明提供新的下式（I）的苯并咪唑衍生物及其盐：其中R 1表示低级烷基或低级烷氧基 - 低级烷基：R 2表示氢原子，卤素原子，烷基 具有1至8个碳原子，芳基等; R3表示低级烷基，低级烯基，芳基，低级烷基芳基，芳基 - 低级烯基，卤代噻吩基，低级烷基氨基或芳基 - 低级烷基氨基; A表示苯环，萘环或吡啶环; X表示卤素原子。 衍生物及其盐具有血糖降低的抑制活性或PDE5抑制活性，可用作药物制剂。
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8.发明公开SULFONAMIDE COMPOUNDS AND MEDICINAL USE THEREOF 失效SULFONAMIDVERBINDUNGEN UND IHRE MEDISINISCHE VERWENDUNG
公开(公告)号：EP0995742A1
公开(公告)日：2000-04-26
申请号：EP98929715.5
申请日：1998-06-24
发明人： KAYAKIRI, Hiroshi , ABE, Yoshito , HAMASHIMA, Hitoshi , SAWADA, Hitoshi , MIZUTANI, Tsuyoshi , YAMASAKI, Noritsugu , ONOMURA, Osamu , NISHIKAWA, Masahiro , HIRAMURA, Takahiro , OKU, Teruo , IMOTO, Takafumi
IPC分类号： C07D215/48 , C07D231/56 , C07D235/26 , C07D239/96 , C07D241/52 , C07D249/18 , C07D307/79 , C07D333/56 , C07D333/54 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04 , A61K31/34 , A61K31/38 , A61K31/415 , A61K31/47 , A61K31/495 , A61K31/505
CPC分类号： C07D241/52 , C07D215/48 , C07D231/56 , C07D239/96 , C07D249/18 , C07D307/79 , C07D333/54 , C07D333/62 , C07D405/12 , C07D409/12 , C07D471/04 , C07D487/04 , C07D495/04
摘要： A sulfonamide compound of the formula (I):
R 1 -SO 2 NHCO-A-X-R 2 (I)
wherein R 1 is alkyl, alkenyl, alkynyl and the like; A is an optionally substituted heteropolycyclic group except benzimidazolyl, indolyl, 4,7-dihydrobenzimidazolyl and 2,3-dihydrobenzoxazinyl; X is alkylene, oxa, oxa(lower)alkylene and the like; and R 2 is optionally substituted aryl, substituted biphenylyl and the like, a salt thereof and a pharmaceutical composition comprising the same. The sulfonamide compound is effective for the diseases treatable based on their blood sugar level-depressing activity, cGMP-PDE (especially PDE-V)-inhibiting activity, smooth muscle relaxing activity, bronchodilating activity, vasodilating activity, smooth muscle cell suppressing activity, and antiallergic activity.摘要翻译： 式（I）的磺酰胺化合物：R 1 -SO 2 NHCO-A-X-R 2其中R 1是烷基，烯基，炔基等; A是任选取代的杂多环基团，除了苯并咪唑基，吲哚基，4,7-二氢苯并咪唑基和2,3-二氢苯并恶嗪基; X是亚烷基，氧杂，氧杂（低级）亚烷基等; R 2是任选取代的芳基，取代的联苯基等，其盐和包含它们的药物组合物。 磺胺类化合物基于其血糖抑制活性，cGMP-PDE（特别是PDE-V）抑制活性，平滑肌松弛活性，支气管扩张活性，血管舒张活性，平滑肌细胞抑制活性，对于可治疗的疾病是有效的，以及 抗过敏活性。
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公开(公告)号：EP0879233B1
公开(公告)日：2003-08-13
申请号：EP97901799.3
申请日：1997-01-31
IPC分类号： C07D401/12 , A61K31/395 , C07D401/14 , C07D409/14
CPC分类号： C07D401/14 , C07D401/12 , C07D409/14
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10.发明公开IMIDAZOLE COMPOUNDS AND MEDICINAL USE THEREOF 有权IMIDAZOL VERBINDUNGEN UND IHRE MEDISINISCHE VERWENDUNG
公开(公告)号：EP1142879A1
公开(公告)日：2001-10-10
申请号：EP99959929.3
申请日：1999-12-20
发明人： KAYAKIRI, Hiroshi , ABE, Yoshito , HAMASHIMA, Hitoshi , SAWADA, Hitoshi , ISHIBASHI, Naoki , SETOI, Hiroyuki , OKU, Teruo , YAMASAKI, Noritsugu , IMOTO, Takafumi , HIRAMURA, Takahiro
IPC分类号： C07D233/54 , C07D233/64 , C07D233/68 , C07D401/06 , C07D405/10 , C07D409/10 , A61K31/4174 , A61K31/4178 , A61P3/10 , A61P43/00
CPC分类号： C07D233/64 , C07D233/90 , C07D233/94 , C07D405/10 , C07D409/10 , C07D409/12
摘要： Imidazole compounds represented by general formula (I):
wherein each symbol is as defined in the specification, and salts thereof, and a pharmaceutical composition containing same are provided. These compounds are useful in treating the diseases curable based on a hypoglycemic action, and the diseases curable based on a cGMP-PDE inhibitory action, a smooth muscle relaxing action, a bronchodilating action, a vasodilating action, a smooth muscle cell inhibitory action and an allergy inhibitory action.摘要翻译： 提供由通式（I）表示的咪唑化合物：其中各符号如说明书中所定义，其盐，以及含有其的药物组合物。 这些化合物可用于治疗基于降血糖作用可治疗的疾病，以及基于cGMP-PDE抑制作用，平滑肌松弛作用，支气管扩张作用，血管扩张作用，平滑肌细胞抑制作用和 过敏抑制作用。
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