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1.发明授权
公开(公告)号：EP0807105B1
公开(公告)日：2004-06-16
申请号：EP95935563.7
申请日：1995-10-25
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D215/16 , A61K31/47 , C07D471/02 , A61K31/395 , C07D215/26 , C07D471/04
CPC分类号： C07D401/12 , C07D215/26 , C07D215/40 , C07D215/42 , C07D215/48 , C07D241/40 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
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2.发明公开PYRIDOPYRIMIDONES, QUINOLINES AND FUSED N-HERETOCYCLES AS BRADYKININ ANTAGONISTS 失效PYRIDOPYRIMIDINONE，CHINO线和融合N-杂环缓激肽拮抗剂
公开(公告)号：EP0807105A1
公开(公告)日：1997-11-19
申请号：EP95935563.0
申请日：1995-10-25
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D237 , A61K31 , A61P29 , A61P37 , A61P43 , C07D215 , C07D239 , C07D241 , C07D401 , C07D403 , C07D413 , C07D417 , C07D471
CPC分类号： C07D401/12 , C07D215/26 , C07D215/40 , C07D215/42 , C07D215/48 , C07D241/40 , C07D401/14 , C07D403/12 , C07D413/14 , C07D417/12 , C07D417/14 , C07D471/04
摘要： The invention relates to Pyridopyrimidones, Quinolines and fused N-heterocyclic compounds of formula (I) wherein Z is a group of the formula (a) or (b) in which X1 is N or C-R1, X2 is N or C-R9, X3 is N or C-R2, R1 is lower alkyl, R2 is hydrogen, lower alkyl, etc., R9 is hydrogen or lower alkyl, R3 is halogen, etc., R4 is halogen, etc., R5 is a group of formula (c), etc., A is lower alkylene, and Y is O, etc., and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to methods of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.
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公开(公告)号：EP0876345B1
公开(公告)日：2004-08-18
申请号：EP96933647.8
申请日：1996-10-15
发明人： OKU, Teruo , KAWAI, Yoshio , SATOH, Shigeki , YAMAZAKI, Hitoshi , KAYAKIRI, Natsuko , URANO, Yasuharu , YOSHIHARA, Kousei , YOSHIDA, Noriko
IPC分类号： C07D215/40 , A61K31/47 , A61K31/54 , A61K31/495 , C07D401/12
CPC分类号： C07D231/12 , C07D215/40 , C07D215/42 , C07D215/44 , C07D215/46 , C07D215/48 , C07D215/54 , C07D215/56 , C07D215/60 , C07D221/12 , C07D233/56 , C07D237/28 , C07D239/74 , C07D239/88 , C07D241/42 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/14 , C07F7/0812 , C07F7/1856
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4.发明授权QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS 失效喹啉，其制造方法相同，它们作为药物
公开(公告)号：EP0900203B1
公开(公告)日：2003-03-19
申请号：EP97919665.6
申请日：1997-04-24
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D215/26 , C07D401/04 , C07D401/14 , C07D401/12 , A61K31/47
CPC分类号： C07D231/12 , C07D215/26 , C07D215/42 , C07D233/56 , C07D249/08 , C07D401/12
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5.发明公开QUINOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS 失效喹啉，用于生产及其作为coorperation
公开(公告)号：EP0900203A1
公开(公告)日：1999-03-10
申请号：EP97919665.0
申请日：1997-04-24
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
CPC分类号： C07D231/12 , C07D215/26 , C07D215/42 , C07D233/56 , C07D249/08 , C07D401/12
摘要： This invention relates to a compound of formula (I) wherein R1 is lower alkyl, R2 is heterocyclic group, etc., R3 is hydrogen, lower alkyl or halogen, R4 is lower alkyl or halogen, R5 is amino substituted with substituent(s) selected from the group consisting of lower alkyl and acyl, etc., and A is lower alkylene, and pharmaceutically acceptable salts thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method of using the same therapeutically in the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human beings or animals.
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公开(公告)号：EP0876345A1
公开(公告)日：1998-11-11
申请号：EP96933647.0
申请日：1996-10-15
发明人： OKU, Teruo , KAWAI, Yoshio , SATOH, Shigeki , YAMAZAKI, Hitoshi , KAYAKIRI, Natsuko , URANO, Yasuharu , YOSHIHARA, Kousei , YOSHIDA, Noriko
IPC分类号： A61K31 , A61P19 , C07D215 , C07D221 , C07D237 , C07D239 , C07D241 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413 , C07D417 , C07D471 , C07D495 , C07D513 , C07D521 , C07F7
CPC分类号： C07D231/12 , C07D215/40 , C07D215/42 , C07D215/44 , C07D215/46 , C07D215/48 , C07D215/54 , C07D215/56 , C07D215/60 , C07D221/12 , C07D233/56 , C07D237/28 , C07D239/74 , C07D239/88 , C07D241/42 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/12 , C07D401/14 , C07D403/04 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D495/04 , C07D513/14 , C07F7/0812 , C07F7/1856
摘要： This invention relates to a compound of formula (I), wherein R1 is a heterocyclic group or aryl, each of which may be substituted with suitable substituent(s), A is -CONH- or -NHCO-, n is an integer of 0 or 1, and (II) is a group of formula (III), in which R?2, R3 and R4¿ are each hydrogen, halogen, etc., R5 is hydrogen or lower alkyl, R6 is hydrogen, halogen, lower alkyl, etc., and R7 is hydrogen, substituted lower alkyl, a heterocyclic group, etc., and pharmaceutically acceptable salt thereof, to processes for preparation thereof, to a pharmaceutical composition comprising the same, and to a method for the prevention and/or the treatment of bone diseases caused by abnormal bone metabolism in human beings or animals.
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公开(公告)号：EP0774462A1
公开(公告)日：1997-05-21
申请号：EP95926025.8
申请日：1995-07-25
发明人： OKU, Teruo , KAYAKIRI, Hiroshi , SATOH, Shigeki , ABE, Yoshito , SAWADA, Yuki , INOUE, Takayuki , TANAKA, Hirokazu
IPC分类号： C07D235/06 , C07D235/26 , C07D263/56 , C07D263/58 , C07D277/66 , C07D277/68 , C07D277/70 , C07D307/79
CPC分类号： C07D209/48 , C07D235/06 , C07D235/08 , C07D235/12 , C07D235/16 , C07D235/26 , C07D235/28 , C07D235/30 , C07D263/56 , C07D277/64 , C07D307/79 , C07D307/80 , C07D307/84 , C07D401/12 , C07D401/14 , C07D403/12 , C07D413/12 , C07F7/1856
摘要： This invention relates to a heterocyclic compound of the formula :
wherein
a group of the formula : is a group of the formula :
etc.,
X is O, S or N-R 5 ,
R 1 is lower alkyl, etc.,
R 5 is hydrogen, lower alkyl, etc.,
R 2 is hydrogen, halogen, lower alkyl, etc.,
R 3 is halogen, lower alkyl, etc.,
R 4 is amino optionally having suitable substituent(s),
and
A is lower alkylene,
and a salt thereof, to processes for preparation thereof, and to a pharmaceutical composition comprising the same for the prevention and/or the treatment of bradykinin or its analogues mediated diseases in human being or animals.摘要翻译： 本发明涉及下式的杂环化合物：其中下列基团为：下式基团：CHEM等，X为O，S或NR 5，R 1， 是低级烷基等，R 5是氢，低级烷基等，R 2是氢，卤素，低级烷基等，R 3是卤素，低级烷基等， 4>是任选具有合适取代基的氨基，A是低级亚烷基及其盐，其制备方法，以及包含其的用于预防和/或治疗缓激肽或其类似物的药物组合物 介导人类或动物的疾病。
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