发明授权
- 专利标题： PROTEIN/(POLY)PEPTIDE LIBRARIES
- 专利标题（中）： 蛋白 - /（POLY）肽文库
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申请号： EP96929278.8申请日： 1996-08-19
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公开(公告)号： EP0859841B1公开(公告)日： 2002-06-19
- 发明人: KNAPPIK, Achim , PACK, Peter , GE, Liming , MORONEY, Simon , PLÜCKTHUN, Andreas
- 申请人： MorphoSys AG
- 申请人地址： Am Klopferspitz 19 82152 Martinsried DE
- 专利权人： MorphoSys AG
- 当前专利权人： MorphoSys AG
- 当前专利权人地址： Am Klopferspitz 19 82152 Martinsried DE
- 代理机构： VOSSIUS & PARTNER
- 优先权： EP95113021 19950818
- 国际公布： WO9708320 19970306
- 主分类号： C12N15/13
- IPC分类号： C12N15/13 ; C12N15/10 ; C12N15/62 ; C12N15/70 ; C12N1/21 ; C07K1/04 ; G01N33/53
摘要：
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
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