公开(公告)号：EP0859841B1

公开(公告)日：2002-06-19

申请号：EP96929278.8

申请日：1996-08-19

申请人： MorphoSys AG

发明人： KNAPPIK, Achim ,  PACK, Peter ,  GE, Liming ,  MORONEY, Simon ,  PLÜCKTHUN, Andreas

IPC分类号： C12N15/13 ,  C12N15/10 ,  C12N15/62 ,  C12N15/70 ,  C12N1/21 ,  C07K1/04 ,  G01N33/53

CPC分类号： C07K1/047 ,  C07K16/00 ,  C07K16/005 ,  C07K16/18 ,  C07K16/242 ,  C07K16/26 ,  C07K16/2854 ,  C07K16/2896 ,  C07K16/44 ,  C07K2317/21 ,  C07K2317/565 ,  C07K2317/622 ,  C07K2319/00 ,  C12N15/10 ,  C12N15/1037 ,  C40B40/02

摘要： The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.