发明授权
- 专利标题： NOVEL TYROSINE KINASE RECEPTORS AND LIGANDS
- 专利标题（中）： 新的酪氨酸激酶受体和配
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申请号： EP96945068.3申请日： 1996-12-13
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公开(公告)号： EP0866860B1公开(公告)日： 2004-03-31
- 发明人: VALENZUELA, David, M. , GLASS, David, J. , BOWEN, David, C. , YANCOPOULOS, George, D.
- 申请人： REGENERON PHARMACEUTICALS, INC.
- 申请人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人： REGENERON PHARMACEUTICALS, INC.
- 当前专利权人地址： 777 Old Saw Mill River Road Tarrytown, NY 10591-6707 US
- 代理机构： Duckworth, Timothy John
- 优先权： US608657 19951215; US644271 19960510
- 国际公布： WO1997021811 19970619
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12N15/16 ; C12N15/70 ; C12N15/81 ; C12N15/85 ; C12N5/10 ; C12N1/19 ; C12N1/21 ; C12Q1/68 ; C12P21/02 ; C07K14/575 ; C07K16/26 ; A61K38/22 ; A61K48/00 ; G01N33/53
摘要：
The present invention provides for a gene, designated as musk , that encodes a novel tyrosine kinase receptor expressed in high levels in denervated muscle. The invention also provides for an isolated polypeptide which activates MuSK receptor. The invention further provides for a polypeptide which is functionally equivalent to the MuSK activating polypeptide. The invention also provides assay systems that may be used to detect and/or measure ligands that bind the musk gene product. The present invention also provides for diagnostic and therapeutic methods based on molecules that activate MuSK.
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