发明公开
- 专利标题: N-SUBSTITUTED AZAHETEROCYCLIC COMPOUNDS
- 专利标题(中): N-取代的亚杂环化合物
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申请号: EP97941882.0申请日: 1997-10-02
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公开(公告)号: EP0934313A1公开(公告)日: 1999-08-11
- 发明人: ANDERSEN, Henrik, Sune , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , ANDERSEN, Knud, Erik , POLIVKA, Zdenek , MIKSIK, Frantisek
- 申请人: NOVO NORDISK A/S
- 申请人地址: Novo Allé 2880 Bagsvaerd DK
- 专利权人: NOVO NORDISK A/S
- 当前专利权人: NOVO NORDISK A/S
- 当前专利权人地址: Novo Allé 2880 Bagsvaerd DK
- 优先权: DK19960001088 19961004
- 国际公布: WO1998015549 19980416
- 主分类号: A61K31
- IPC分类号: A61K31 ; A61P3 ; A61P17 ; A61P25 ; A61P29 ; C07D207 ; C07D211 ; C07D401 ; C07D405 ; C07D409 ; C07D417
摘要:
The present invention relates to novel N-substituted azaheterocyclic carboxylic acids of general formula (I) wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.
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