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公开(公告)号：EP0934313A1
公开(公告)日：1999-08-11
申请号：EP97941882.0
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： ANDERSEN, Henrik, Sune , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , ANDERSEN, Knud, Erik , POLIVKA, Zdenek , MIKSIK, Frantisek
IPC分类号： A61K31 , A61P3 , A61P17 , A61P25 , A61P29 , C07D207 , C07D211 , C07D401 , C07D405 , C07D409 , C07D417
CPC分类号： C07D207/08 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids of general formula (I) wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.
摘要翻译： 本发明涉及通式（I）的新的N-取代的氮杂环羧酸，其中X，Y，Z，R 1，R 2和r如说明书的详细部分所定义，或其盐，及其制备方法 ，涉及含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎症病症的用途，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用以及它们用于治疗由 与胰岛素拮抗肽的分泌和循环有关。
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公开(公告)号：EP0851865B1
公开(公告)日：2002-07-17
申请号：EP96930027.6
申请日：1996-09-12
申请人： NOVO NORDISK A/S
发明人： HOHLWEG, Rolf , JOERGENSEN, Tine, Krogh , ANDERSEN, Knud, Erik , OLSEN, Uffe, Bang , MADSEN, Peter , POLIVKA, Zendék , KÖNIGOVA, Otylie , MIKSIK, Frantisek , KOVANDOVA, Martina , SILHANKOVA, Alexandra , SINDELAR, Karel
IPC分类号： C07D405/06 , C07D405/12 , C07D273/01 , A61K31/455 , A61K31/445 , A61K31/40
CPC分类号： C07D405/06 , C07D405/12 , C07D413/06
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公开(公告)号：EP0934313B1
公开(公告)日：2003-05-14
申请号：EP97941882.9
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： ANDERSEN, Henrik, Sune , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , ANDERSEN, Knud, Erik , POLIVKA, Zdenek , MIKSIK, Frantisek
IPC分类号： C07D409/06 , C07D207/08 , C07D401/06 , C07D417/06 , C07D211/60 , A61K31/445 , A61K31/41 , A61K31/535
CPC分类号： C07D207/08 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids of general formula (I) wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.
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公开(公告)号：EP0851865A1
公开(公告)日：1998-07-08
申请号：EP96930027.0
申请日：1996-09-12
申请人： NOVO NORDISK A/S
发明人： HOHLWEG, Rolf , JOERGENSEN, Tine, Krogh , ANDERSEN, Knud, Erik , OLSEN, Uffe, Bang , MADSEN, Peter , POLIVKA, Zendék , KÖNIGOVA, Otylie , MIKSIK, Frantisek , KOVANDOVA, Martina , SILHANKOVA, Alexandra , SINDELAR, Karel
CPC分类号： C07D405/06 , C07D405/12 , C07D413/06
摘要： A compound of formula (I), wherein R?1 and R2¿ independently are hydrogen, halogen, trifluoromethyl, hydroxy, C¿1-6?-alkyl or C1-6-alkoxy; and R?3¿ is hydrogen or C¿1-3?-alkyl; and A is C1-3-alkylene; and Y is >CH-CH2-, >C=CH-, >CH-O-, >C=N-, >N-CH2- wherein only the underscored atom participates in the ring system, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation.
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