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公开(公告)号：EP0991621A1
公开(公告)日：2000-04-12
申请号：EP98929235.4
申请日：1998-06-22
申请人： NOVO NORDISK A/S
发明人： ANDERSEN, Knud, Erik , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , FISCHER, Erik , OLSEN, Uffe, Bang , POLIVKA, Zdenek , SINDELAR, Karel , VALENTA, Vladimir
IPC分类号： C07D211/34 , C07D401/06 , C07D405/06 , C07D409/06 , A61K31/445
CPC分类号： C07D401/06 , C07D211/34 , C07D405/06 , C07D409/06
摘要： The present invention relates to novel N-sustituted azaheterocyclic compounds of general formula (I) wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description, or salts, thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译： 本发明涉及通式（I）的新型N-取代的氮杂环化合物或其盐，其中X，Y，Z，R 1，R 2和r如本说明书的详细部分所定义，或其盐 制备含有它们的组合物及其用于临床治疗疼痛，痛觉过敏和/或炎症状况的用途，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理作用以及它们用于治疗由 或与胰岛素拮抗肽的分泌和循环有关， 非胰岛素依赖性糖尿病（NIDDM）和衰老相关肥胖。
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公开(公告)号：EP0934313A1
公开(公告)日：1999-08-11
申请号：EP97941882.0
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： ANDERSEN, Henrik, Sune , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , ANDERSEN, Knud, Erik , POLIVKA, Zdenek , MIKSIK, Frantisek
IPC分类号： A61K31 , A61P3 , A61P17 , A61P25 , A61P29 , C07D207 , C07D211 , C07D401 , C07D405 , C07D409 , C07D417
CPC分类号： C07D207/08 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids of general formula (I) wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.
摘要翻译： 本发明涉及通式（I）的新的N-取代的氮杂环羧酸，其中X，Y，Z，R 1，R 2和r如说明书的详细部分所定义，或其盐，及其制备方法 ，涉及含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎症病症的用途，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用以及它们用于治疗由 与胰岛素拮抗肽的分泌和循环有关。
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公开(公告)号：EP0934312B1
公开(公告)日：2003-03-19
申请号：EP97941884.5
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： HOHLWEG, Rolf , MADSEN, Peter , JORGENSEN, Tine, Krogh , ANDERSEN, Knud, Erik , WATSON, Brett , POLIVKA, Zdenek , KONIGOVA, Otylie , SILHANKOVA, Alexandra , VALENTA, Vladimir
IPC分类号： C07D405/12 , C07D407/12 , C07D213/74 , C07D401/12 , C07D295/073 , C07D295/155 , C07D409/12 , A61K31/495
CPC分类号： C07D213/74 , C07C2603/78 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to 1,4-disubstituted piperazines of general formula (I), wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译： 本发明涉及以下通式的1,4-二取代哌嗪其中X，Y，Z，R 1，R 2和r如在本说明书的详细部分中所定义或其盐，其制备方法，组合物 并且用于临床治疗疼痛，痛觉过敏和/或炎性疾病，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理学作用，以及其用于治疗由 胰岛素拮抗肽的分泌和循环，例如， 非胰岛素依赖性糖尿病（NIDDM）和衰老相关性肥胖。
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公开(公告)号：EP0934314A1
公开(公告)日：1999-08-11
申请号：EP97941881.0
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： JORGENSEN, Tine, Krogh , FISCHER, Erling , HOHLWEG, Rolf , ANDERSEN, Knud, Erik , OLSEN, Uffe, Bang , POLIVKA, Zdenek , VALENTA, Vladimir , SINDELAR, Karel
CPC分类号： C07D405/12 , C07D409/12 , C07D411/12
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of general formula (I) wherein X, Y, Z, R?1, R1a, R2, R2a¿, p, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.
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5.发明公开
公开(公告)号：EP1578716A1
公开(公告)日：2005-09-28
申请号：EP03779752.9
申请日：2003-12-18
申请人： NOVO NORDISK A/S
IPC分类号： C07C59/68 , C07C69/612 , C07C69/734 , C07C229/36 , C07D333/10 , C07D213/24 , C07D487/04 , A61P3/10 , A61P3/04 , A61K31/215 , A61K31/216 , A61K31/381 , A61K31/341 , A61K31/395 , A61K31/225
CPC分类号： C07D213/74 , A61K31/215 , A61K31/216 , A61K31/225 , A61K31/341 , A61K31/381 , A61K31/395 , C07C59/68 , C07C59/72 , C07C69/734 , C07C323/20 , C07C323/52 , C07C2603/10 , C07C2603/18 , C07D263/32
摘要： A novel class of dicarboxylic acid derivatives, the use of these compounds as phar-maceutical compositions, pharmaceutical compositions comprising the compounds and meth-ods of treatment employing these compounds and compositions. The present compounds may be useful in the treatment and/or prevention of conditions mediated by Peroxisome Prolifera-tor-Activated Receptors (PPAR).
摘要翻译： 一类新的二羧酸衍生物，这些化合物作为药物组合物的用途，包含这些化合物的药物组合物和使用这些化合物和组合物的处理方法。 本发明化合物可用于治疗和/或预防由过氧化物酶体释放激活受体（PPAR）介导的病症。
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公开(公告)号：EP0934313B1
公开(公告)日：2003-05-14
申请号：EP97941882.9
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： ANDERSEN, Henrik, Sune , JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , ANDERSEN, Knud, Erik , POLIVKA, Zdenek , MIKSIK, Frantisek
IPC分类号： C07D409/06 , C07D207/08 , C07D401/06 , C07D417/06 , C07D211/60 , A61K31/445 , A61K31/41 , A61K31/535
CPC分类号： C07D207/08 , C07D211/60 , C07D211/62 , C07D401/06 , C07D405/06 , C07D409/06 , C07D417/06
摘要： The present invention relates to novel N-substituted azaheterocyclic carboxylic acids of general formula (I) wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides.
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公开(公告)号：EP0934312A1
公开(公告)日：1999-08-11
申请号：EP97941884.0
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： HOHLWEG, Rolf , MADSEN, Peter , JORGENSEN, Tine, Krogh , ANDERSEN, Knud, Erik , WATSON, Brett , POLIVKA, Zdenek , KONIGOVA, Otylie , SILHANKOVA, Alexandra , VALENTA, Vladimir
IPC分类号： C07D295 , A61K31 , A61P3 , A61P17 , A61P25 , A61P29 , C07D213 , C07D401 , C07D403 , C07D405 , C07D409 , C07D413
CPC分类号： C07D213/74 , C07C2603/78 , C07D213/79 , C07D295/073 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12
摘要： The present invention relates to 1,4-disubstituted piperazines of general formula (I), wherein X, Y, Z, R1, R2 and r are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for the treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
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公开(公告)号：EP0991633A1
公开(公告)日：2000-04-12
申请号：EP98929233.9
申请日：1998-06-22
申请人： NOVO NORDISK A/S
发明人： JORGENSEN, Tine, Krogh , ANDERSEN, Knud, Erik , HOHLWEG, Rolf , OLSEN, Uffe, Bang , FISCHER, Erik , POLIVKA, Zdenek , SINDELAR, Karel
IPC分类号： C07D295/108 , C07D211/70 , C07D409/04 , C07D409/14
CPC分类号： C07D295/15 , C07D211/70 , C07D409/04 , C07D409/14
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of general formula (I), wherein X, Y, Z, R1, R2 and m are as defined in the detailed part of the present description, or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation, as well as their use for treatment of indications caused by or related to the secretion and circulation of insulin antagonising peptides, e.g. non-insulin-dependent diabetes mellitus (NIDDM) and ageing-associated obesity.
摘要翻译： 本发明涉及通式（I）的新的N-取代的氮杂环化合物或其盐，其中X，Y，Z，R 1，R 2和m如本说明书的详细部分中所定义，或其盐 制备含有它们的组合物及其用于临床治疗疼痛，痛觉过敏和/或炎症状况的用途，其中C-纤维通过引发神经源性疼痛或炎症而发挥病理生理作用，以及它们用于治疗引起的适应症 通过或与胰岛素拮抗肽的分泌和循环有关，例如， 非胰岛素依赖性糖尿病（NIDDM）和衰老相关肥胖。
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公开(公告)号：EP0934306A1
公开(公告)日：1999-08-11
申请号：EP97941883.0
申请日：1997-10-02
申请人： NOVO NORDISK A/S
发明人： JORGENSEN, Tine, Krogh , HOHLWEG, Rolf , MADSEN, Peter , ANDERSEN, Knud, Erik , TREPPENDAHL, Svend , OLSEN, Uffe, Bang , POLIVKA, Zdenek , SILHANKOVA, Alexandra , SINDELAR, Karel , VALENTA, Vladimir , KALISZ, Tomas
CPC分类号： C07D401/06 , A61K31/445 , A61K31/55 , C07D211/60 , C07D401/10 , C07D401/12 , C07D403/06
摘要： The present invention relates to novel N-substituted azaheterocyclic compounds of general formula (I), wherein X, Y, Z, A, R1, R2, r and s are as defined in the detailed part of the present description or salts thereof, to methods for their preparation, to compositions containing them, and to their use for the clinical treatment of painful, hyperalgesic and/or inflammatory conditions in which C-fibers play a pathophysiological role by eliciting neurogenic pain or inflammation as well as their use for treatment of indications caused by or related to secretion and circulation of insulin antagonising peptides.
摘要翻译： 本发明涉及通式（I）的新的N-取代的氮杂环化合物，其中X，Y，Z，A，R 1，R 2，r和s如本说明书的详细部分或其盐所定义， 制备它们的方法，含有它们的组合物，以及它们用于临床治疗疼痛，痛觉过敏和/或炎症状况的应用，其中C-纤维通过引发神经源性疼痛或炎症发挥病理生理作用以及它们用于治疗 由胰岛素拮抗肽的分泌和循环引起或与其有关的适应症。
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