发明公开
EP0940387A4 PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME 失效
苯乙醇胺化合物与应用,BETA3激动剂方法生产及其制备中间产品

PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME
摘要:
Phenylethanolamine compounds represented by general formula (I) and pharmacologically acceptable salts thereof which have a potent effect of stimulating β3 adrenaline receptors and a high selectivity for β3 adrenaline receptors, wherein R1 represents hydrogen or halogeno; R2 represents hydrogen, hydroxy, lower alkoxy, lower alkoxy substituted by one or two lower alkoxycarbonyl or carboxy groups, lower alkoxy substituted by lower alkylaminocarbonyl optionally substituted by lower alkoxy, lower alkoxy substituted by cyclic C4-6 aminocarbonyl, lower alkoxycarbonyl, or carboxy; R3 represents hydrogen, hydroxy, lower alkoxy, or lower alkoxy substituted by one or two lower alkoxycarbonyl or carboxy groups, or R2 and R3 may be bonded to each other to thereby form methylenedioxy substituted by carboxy or lower alkoxycarbonyl; and m and n are each 0 or 1.
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