发明公开
- 专利标题: PHENYLETHANOLAMINE COMPOUNDS USEFUL AS BETA3 AGONIST, PROCESS FOR PRODUCING THE SAME, AND INTERMEDIATES IN THE PRODUCTION OF THE SAME
- 专利标题(中): 苯乙醇胺化合物与应用,BETA3激动剂方法生产及其制备中间产品
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申请号: EP96935424申请日: 1996-10-24
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公开(公告)号: EP0940387A4公开(公告)日: 2000-07-05
- 发明人: TSUCHIYA SUSUMU , YASUDA NOBUYUKI , MATSUMOTO TOSHIFUMI , HIRATSUKA KOZO , IIZUKA HIROYUKI , HUKUZAKI ATSUSI , MATSUNAGA KOUICHI
- 申请人: MITSUBISHI TOKYO PHARM INC
- 专利权人: MITSUBISHI TOKYO PHARM INC
- 当前专利权人: MITSUBISHI TOKYO PHARM INC
- 优先权: JP27855495 1995-10-26; JP24962296 1996-09-20
- 主分类号: C07C215/42
- IPC分类号: C07C215/42 ; C07C217/74 ; C07C219/24 ; C07C235/36 ; C07D235/08 ; C07D295/185 ; C07D317/46 ; A61K31/135 ; C07C49/255 ; C07C49/753 ; C07C211/40 ; C07C213/02 ; C07C213/04 ; C07C213/08
摘要:
Phenylethanolamine compounds represented by general formula (I) and pharmacologically acceptable salts thereof which have a potent effect of stimulating β3 adrenaline receptors and a high selectivity for β3 adrenaline receptors, wherein R1 represents hydrogen or halogeno; R2 represents hydrogen, hydroxy, lower alkoxy, lower alkoxy substituted by one or two lower alkoxycarbonyl or carboxy groups, lower alkoxy substituted by lower alkylaminocarbonyl optionally substituted by lower alkoxy, lower alkoxy substituted by cyclic C4-6 aminocarbonyl, lower alkoxycarbonyl, or carboxy; R3 represents hydrogen, hydroxy, lower alkoxy, or lower alkoxy substituted by one or two lower alkoxycarbonyl or carboxy groups, or R2 and R3 may be bonded to each other to thereby form methylenedioxy substituted by carboxy or lower alkoxycarbonyl; and m and n are each 0 or 1.
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