发明授权
EP1108058B1 EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
有权
EVOLUTION全细胞和生物体BY回归序列重组
- 专利标题： EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION
- 专利标题（中）： EVOLUTION全细胞和生物体BY回归序列重组
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申请号： EP99935574.6申请日： 1999-07-15
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公开(公告)号： EP1108058B1公开(公告)日： 2006-02-08
- 发明人: DEL CARDAYRE, Stephen , TOBIN, Matthew , STEMMER, Willem, P., C. , NESS, Jon, E. , MINSHULL, Jeremy , PATTEN, Phillip, A. , SUBRAMANIAN, Venkiteswatan , CASTLE, Linda, A. , KREBBER, Claus, M. , BASS, Steve , ZHANG, Ying-Xin , COX, Tony , HUISMAN, Gjalt , YUAN, Ling , AFFHOLTER, Joseph, A.
- 申请人： Maxygen, Inc.
- 申请人地址： 515, Galveston Drive Redwood City, CA 94063 US
- 专利权人： Maxygen, Inc.
- 当前专利权人： Maxygen, Inc.
- 当前专利权人地址： 515, Galveston Drive Redwood City, CA 94063 US
- 代理机构： Hallybone, Huw George
- 优先权： US116188 19980715
- 国际公布： WO2000004190 20000127
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/00
摘要：
The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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