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1.发明公开EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION 有权EVOLUTION全细胞和生物体BY回归序列重组
公开(公告)号：EP1108058A1
公开(公告)日：2001-06-20
申请号：EP99935574.6
申请日：1999-07-15
申请人： Maxygen, Inc.
发明人： DEL CARDAYRE, Stephen , TOBIN, Matthew , STEMMER, Willem, P., C. , NESS, Jon, E. , MINSHULL, Jeremy , PATTEN, Phillip, A. , SUBRAMANIAN, Venkiteswatan , CASTLE, Linda, A. , KREBBER, Claus, M. , BASS, Steve , ZHANG, Ying-Xin , COX, Tony , HUISMAN, Gjalt , YUAN, Ling , AFFHOLTER, Joseph, A.
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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2.发明授权EVOLUTION OF WHOLE CELLS AND ORGANISMS BY RECURSIVE SEQUENCE RECOMBINATION 有权EVOLUTION全细胞和生物体BY回归序列重组
公开(公告)号：EP1108058B1
公开(公告)日：2006-02-08
申请号：EP99935574.6
申请日：1999-07-15
申请人： Maxygen, Inc.
发明人： DEL CARDAYRE, Stephen , TOBIN, Matthew , STEMMER, Willem, P., C. , NESS, Jon, E. , MINSHULL, Jeremy , PATTEN, Phillip, A. , SUBRAMANIAN, Venkiteswatan , CASTLE, Linda, A. , KREBBER, Claus, M. , BASS, Steve , ZHANG, Ying-Xin , COX, Tony , HUISMAN, Gjalt , YUAN, Ling , AFFHOLTER, Joseph, A.
CPC分类号： C12N15/102 , C07K14/245 , C12N15/1027 , C12N15/8271 , C12N15/8273 , C12N15/8279 , C12P17/162 , C12Q1/68 , C12Q1/6811 , C12Q1/6827 , C12R1/465
摘要： The invention provides methods employing iterative cycles of recombination and selection/screening for evolution of whole cells and organisms toward acquisition of desired properties. Examples of such properties include enhanced recombinogenicity, genome copy number, and capacity for expression and/or secretion of proteins and secondary metabolites.
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