发明公开
- 专利标题： TUMOR ANTIGENS AND CTL CLONES ISOLATED BY A NOVEL PROCEDURE
- 专利标题（中）： 肿瘤抗原和CTL克隆由一个新的程序分离
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申请号： EP99970091.7申请日： 1999-09-15
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公开(公告)号： EP1117679A2公开(公告)日： 2001-07-25
- 发明人: CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
- 申请人： LUDWIG INSTITUTE FOR CANCER RESEARCH
- 申请人地址： 1345 Avenue of the Americas New York,New York 10105 US
- 专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH
- 当前专利权人： LUDWIG INSTITUTE FOR CANCER RESEARCH
- 当前专利权人地址： 1345 Avenue of the Americas New York,New York 10105 US
- 代理机构： HOFFMANN - EITLE
- 优先权： US165863 19981002; US289350 19990409
- 国际公布： WO0020445 20000413
- 主分类号： C07K7/06
- IPC分类号： C07K7/06 ; C12N5/08 ; C12N15/11 ; A61K38/08
摘要：
The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
公开/授权文献
- EP1117679B9 TUMOR ANTIGENS AND CTL CLONES ISOLATED BY A NOVEL PROCEDURE 公开/授权日：2010-07-07
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