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公开(公告)号：EP1117679B1
公开(公告)日：2009-11-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
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公开(公告)号：EP1117679B9
公开(公告)日：2010-07-07
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
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公开(公告)号：EP1117679A2
公开(公告)日：2001-07-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
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公开(公告)号：EP1012283A1
公开(公告)日：2000-06-28
申请号：EP98945923.5
申请日：1998-09-04
发明人： THIELEMANS, Kris , HEIRMAN, Carlo , CORTHALS, Jurgen , CHAUX, Pascal , STROOBANT, Vincent , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUITEN, Rosalie
IPC分类号： C12N15/12 , C07K14/705 , C07K19/00 , G01N33/53 , G01N33/68 , A61K38/17 , A61K35/26 , C07K16/30 , C12N5/08
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4+T lymphocytes. Methods and products are also provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
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公开(公告)号：EP1012283B1
公开(公告)日：2009-06-03
申请号：EP98945923.5
申请日：1998-09-04
发明人： THIELEMANS, Kris , HEIRMAN, Carlo , CORTHALS, Jurgen , CHAUX, Pascal , STROOBANT, Vincent , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , LUITEN, Rosalie
IPC分类号： C12N15/12 , C07K14/705 , C07K19/00 , G01N33/53 , G01N33/68 , A61K38/17 , A61K35/26 , C07K16/30 , C12N5/08
CPC分类号： C07K14/4748 , A61K39/00 , C07K2319/00
摘要： The invention describes HLA class II binding peptides encoded by the MAGE-3 tumor associated gene, as well as nucleic acids encoding such peptides and antibodies relating thereto. The peptides stimulate the activity and proliferation of CD4 T lymphocytes. Methods and products are also provided for diagnosing and treating conditions characterized by expression of the MAGE-3 gene.
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6.发明公开MAGE ANTIGENIC PEPTIDES WHICH BIND HLA-B35 AND HLA-B44 审中-公开AN HLA-B35 UND HLA-B44 BINDENDE MAGE ANTIGENE肽
公开(公告)号：EP1266221A1
公开(公告)日：2002-12-18
申请号：EP01913365.1
申请日：2001-01-19
发明人： LUITEN, Rosalie , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , STROOBANT, Vincent , DEMOTTE, Nathalie , SCHULTZ, Erwin
CPC分类号： G01N33/56972 , A61K2039/505 , C07K16/30 , G01N33/6893
摘要： The invention provides antigenic peptides derived from MAGE-A1 polypeptides and presented by HLA-B35 and HLA-B44 molecules. Antigenic peptides derived from MAGE-A3 polypeptides and presented by HLA-B35 molecules also are provided. Methods for diagnosis and treatment which involve the polypeptides also are provided.
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