-
公开(公告)号：EP1117679A2
公开(公告)日：2001-07-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
摘要： The present invention relates to isolation of cytotoxic T lymphocyte (CTL) clones. In particular, the present invention relates to isolated CTL clones that are specific for proteins of the MAGE family. The CTL clones of the present invention have been isolated by successive steps of stimulation and testing of lymphocytes with antigen presenting cells which present antigens derived from different expression systems, e.g., from recombinant Yersinia, recombinant Salmonella, or recombinant viruses. The present invention further relates to antigenic peptides as well as the peptide/HLA complexes which are recognized by the isolated CTL clones.
-
2.发明授权TUMOR REJECTION ANTIGEN PRECURSORS, TUMOR REJECTION ANTIGENS AND USES THEREOF 失效负责任TUMORABSTOSSUNG抗原，抗原和PRE及其用途
公开(公告)号：EP0595838B1
公开(公告)日：2004-10-13
申请号：EP92913925.1
申请日：1992-05-22
发明人： BOON, Thierry , VAN DER BRUGGEN, Pierre , VAN DEN EYNDE, Benoit , VAN PEL, Aline , DE PLAEN, Etienne , LURQUIN, Christophe , CHOMEZ, Patrick , TRAVERSARI, Catia
IPC分类号： C12N15/12 , C07K14/00 , A61K39/00 , A61K39/395 , A61K38/00 , G01N33/574 , C12Q1/68 , C12N1/20
CPC分类号： C07K16/30 , A61K38/00 , A61K39/00 , C07K14/4748
摘要： The invention relates to an isolated DNA sequence which codes for an antigen expressed by tumor cells which is recognized by cytotoxic T cells, leading to lysis of the tumor which expresses it. Also described are cells transfected by the DNA sequence, and various therapeutic and diagnostic uses arising out of the properties of the DNA and the antigen for which it codes.
-
公开(公告)号：EP1117679B1
公开(公告)日：2009-11-25
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
-
4.发明授权ISOLATED NONAPEPTIDE DERIVED FROM MAGE-3 GENE AND PRESENTED BY HLA-A1, AND USES THEREOF 失效从MAGE-3基因的和HLA-A1-提出，隔离九肽及其应用
公开(公告)号：EP0658113B1
公开(公告)日：2004-10-20
申请号：EP93920419.4
申请日：1993-08-30
发明人： BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , DE PLAEN, Etienne , LURQUIN, Christophe , TRAVERSARI, Catia
IPC分类号： C07K14/705 , C07K16/30 , G01N33/574
CPC分类号： C07K14/4748 , A61K38/00 , A61K39/00 , C07K16/30
-
5.发明公开VECTEURS ADENOVIRAUX RECOMBINANTS POUR LA THERAPIE GENIQUE DES TUMEURS HUMAINES 失效重组ADENOVIRENVEKTOREN人类癌症基因治疗
公开(公告)号：EP0889969A1
公开(公告)日：1999-01-13
申请号：EP97914375.0
申请日：1997-03-12
发明人： BOON, Falleur , DUFFOUR, Marie-Thérèse , HADDADA, Hedi , LURQUIN, Christophe , PERRICAUDET, Michel , UYTTENHOVEGHESQUIERE, Catherine , WARNIER, Guy
CPC分类号： C07K14/4748 , A61K48/00 , A61K2039/51 , C12N2799/022
摘要： A method for treating human tumours by gene therapy is disclosed. In particular, defective recombinant viruses with a sequence coding for a human tumour-specific antigen, and the use thereof for treating or preventing human tumours, as well as producing specific cytotoxic T-cells (CTLs) in vitro or ex vivo, are disclosed. Pharmaceutical compositions comprising said viruses, particularly in injectable form, are also disclosed.
-
公开(公告)号：EP1117679B9
公开(公告)日：2010-07-07
申请号：EP99970091.7
申请日：1999-09-15
发明人： CHAUX, Pascal , LUITEN, Rosalie , DEMOTTE, Nathalie , DUFFOUR, Marie-Thérèse , LURQUIN, Christophe , TRAVERSARI, Catia , STROOBANT, Vincent , CORNELIS, Guy, R. , BOON-FALLEUR, Thierry , VAN DER BRUGGEN, Pierre , SCHULTZ, Erwin , WARNIER, Guy
CPC分类号： C07K14/4748
-
7.发明公开CLONING OF CDNA OF MAGE'S 5,8,9 AND 11 AND THEIR USES IN DIAGNOSIS OF CANCER 审中-公开将cDNA MAGE'S 5,8,9的克隆和11以及它们在诊断肿瘤杂志
公开(公告)号：EP1194542A1
公开(公告)日：2002-04-10
申请号：EP00912112.0
申请日：2000-03-01
发明人： SERRANO, Alfonso , LETHE, Bernard , LURQUIN, Christophe , DE PLAEN, Etienne , RIMOLDI, Donata , BOON-FALLEUR, Thierry
CPC分类号： C07K14/4748
摘要： The invention relates to cDNA molecules which were isolated and identified in accordance with a method which was developed to facilitate the level of gene expression. Also described are proteins and peptides based upon these cDNA molecules, as well as various diagnostic and therapeutic uses of these materials.
-
8.发明公开ISOLATED NUCLEIC ACID MOLECULES WHICH ARE MEMBERS OF THE MAGE-B FAMILY AND USES THEREOF 失效MAGE-B家族的分离的核酸分子成员，及其应用
公开(公告)号：EP0910669A1
公开(公告)日：1999-04-28
申请号：EP97931048.0
申请日：1997-06-05
CPC分类号： C07K14/4748 , C12Q1/6886 , C12Q2600/158
摘要： The invention relates to members of the MAGE-B family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-B family are found on the Xp arm of the X chromosome rather than on the Xq chromosome, as was the case with the previously identified MAGE genes.
-
9.发明授权VECTEURS ADENOVIRAUX RECOMBINANTS POUR LA THERAPIE GENIQUE DES TUMEURS HUMAINES 失效重组ADENOVIRENVEKTOREN人类癌症基因治疗
公开(公告)号：EP0889969B1
公开(公告)日：2005-11-09
申请号：EP97914375.7
申请日：1997-03-12
发明人： BOON, Falleur , DUFFOUR, Marie-Thérèse , HADDADA, Hedi , LURQUIN, Christophe , PERRICAUDET, Michel , UYTTENHOVEGHESQUIERE, Catherine , WARNIER, Guy
CPC分类号： C07K14/4748 , A61K48/00 , A61K2039/51 , C12N2799/022
-
10.发明公开ISOLATED NUCLEIC ACID MOLECULES WHICH ARE MEMBERS OF THE MAGE-Xp FAMILY AND USES THEREOF 失效MAGE-XP家族的分离的核酸分子成员，并且它们的用途
公开(公告)号：EP0815118A1
公开(公告)日：1998-01-07
申请号：EP96908731.0
申请日：1996-03-11
CPC分类号： C07K14/4748 , C12Q1/6886
摘要： The invention relates to members of the MAGE-Xp family of nucleic acid molecules. These molecules differ from the previously described MAGE nucleic acid molecules in that members of the MAGE-Xp family do not hybridize to the previously identified MAGE sequences. Further, the members of the MAGE-Xp family are found on the Xp arm of the X chromosome rather than on the Xq chromosone, as was the case with the previously identified MAGE genes.
-
-
-
-
-
-
-
-
-
搜索结果
12 条记录 (耗时 0.014 秒)
