发明公开
- 专利标题： ERYTHROPOIETIC COMPOUNDS
- 专利标题（中）： 红细胞生成物质
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申请号： EP99967124.1申请日： 1999-11-23
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公开(公告)号： EP1135493A2公开(公告)日： 2001-09-26
- 发明人: BEALS, John, Michael , GLAESNER, Wolfgang , MICANOVIC, Radmilla , MILLICAN, Rohn, Lee, Jr. , WITCHER, Derrick, Ryan
- 申请人： ELI LILLY AND COMPANY
- 申请人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 专利权人： ELI LILLY AND COMPANY
- 当前专利权人： ELI LILLY AND COMPANY
- 当前专利权人地址： Lilly Corporate Center Indianapolis, Indiana 46285 US
- 代理机构： Denholm, Anna Marie
- 优先权： US110289P 19981130
- 国际公布： WO0032772 20000608
- 主分类号： C12N15/12
- IPC分类号： C12N15/12 ; C12N1/21 ; C07K14/505 ; A61K47/48 ; A61K38/18 ; A01K67/027 ; A61P7/06
摘要：
The present invention addresses the need for better pharmaceutical agents for treating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.
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