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公开(公告)号：EP1135493A2
公开(公告)日：2001-09-26
申请号：EP99967124.1
申请日：1999-11-23
发明人： BEALS, John, Michael , GLAESNER, Wolfgang , MICANOVIC, Radmilla , MILLICAN, Rohn, Lee, Jr. , WITCHER, Derrick, Ryan
IPC分类号： C12N15/12 , C12N1/21 , C07K14/505 , A61K47/48 , A61K38/18 , A01K67/027 , A61P7/06
CPC分类号： C07K14/505 , A01K2217/05 , A61K38/1816 , A61K47/60
摘要： The present invention addresses the need for better pharmaceutical agents for treating anemias by providing polymer derivatized non-glycosylated erythropoietic compounds which show stability and bioactivity in vivo. The invention further provides methods for preparing these derivatived proteins which involves the use of a linkerless aldehyde modification process.
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公开(公告)号：EP1641483B1
公开(公告)日：2008-02-13
申请号：EP04753440.9
申请日：2004-06-10
发明人： GLAESNER, Wolfgang , MILLICAN, Rohn, Lee, Jr. , TIAN, Yu , TSCHANG, Sheng-Hung, Rainbow , VICK, Andrew, Mark
CPC分类号： C07K16/26 , A61K38/00 , C07K14/50 , C07K14/503 , C07K14/605 , C07K2319/30 , C07K2319/75
摘要： The invention provides active therapeutic peptides fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half-life, reduced half antibody formation, and reduced effector activity, while not being immunogenic. The fusion proteins are useful in treating human diseases as well as a variety of other conditions or disorders.
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公开(公告)号：EP1641483A2
公开(公告)日：2006-04-05
申请号：EP04753440.9
申请日：2004-06-10
发明人： GLAESNER, Wolfgang , MILLICAN, Rohn, Lee, Jr. , TIAN, Yu , TSCHANG, Sheng-Hung, Rainbow , VICK, Andrew, Mark
CPC分类号： C07K16/26 , A61K38/00 , C07K14/50 , C07K14/503 , C07K14/605 , C07K2319/30 , C07K2319/75
摘要： The invention provides active therapeutic peptides fused to specific IgG4-Fc derivatives. These fusion proteins have an increased half-life, reduced half antibody formation, and reduced effector activity, while not being immunogenic. The fusion proteins are useful in treating human diseases as well as a variety of other conditions or disorders.
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