发明公开
EP1161525A2 METHODS AND COMPOSITIONS FOR REGULATING MEMORY CONSOLIDATION
审中-公开
方法和组合物用于调节GEDÄCHTNISBEFESTIGENS
- 专利标题： METHODS AND COMPOSITIONS FOR REGULATING MEMORY CONSOLIDATION
- 专利标题（中）： 方法和组合物用于调节GEDÄCHTNISBEFESTIGENS
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申请号： EP00913904.9申请日： 2000-03-13
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公开(公告)号： EP1161525A2公开(公告)日： 2001-12-12
- 发明人: ALBERINI, Cristina, M. , BEAR, Mark, F. , COOPER, Leon, N. , TAUBENFELD, Stephen, M. , WIIG, Kjesten, A.
- 申请人： BROWN UNIVERSITY RESEARCH FOUNDATION
- 申请人地址： 42 Charlesfield Street,P.O. Box 1949 Providence, RI 02912 US
- 专利权人： BROWN UNIVERSITY RESEARCH FOUNDATION
- 当前专利权人： BROWN UNIVERSITY RESEARCH FOUNDATION
- 当前专利权人地址： 42 Charlesfield Street,P.O. Box 1949 Providence, RI 02912 US
- 代理机构： Chapman, Paul Gilmour
- 优先权： US124301P 19990312
- 国际公布： WO0053738 20000914
- 主分类号： C12N15/00
- IPC分类号： C12N15/00 ; A01K67/027 ; A61K49/00 ; A61P25/28 ; A61K35/30
摘要：
The present invention provides methods for identifying genes involved in memory consolidation, and for identifying agents which effect memory consolidation in a mammal. These methods preferably use (1) non-human mammals which have been manipulated to create at least partial disruption of fornix-mediated afferant signalling to the hippocampus, said disruption affecting memory consolidation or (2) non-lesioned mammals which have been subjected to a learning and memory test to provide a learned behavior in the mammal.
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