公开(公告)号：EP1331930A2

公开(公告)日：2003-08-06

申请号：EP01924598.4

申请日：2001-04-02

申请人： BROWN UNIVERSITY RESEARCH FOUNDATION ,  Howard Hughes Medical Institute

发明人： ALBERINI, Cristina, M. ,  BEAR, Mark, F.

IPC分类号： A61K31/00 ,  A61K33/00 ,  A61K38/00 ,  A61K39/00

CPC分类号： C12Q1/6883 ,  A61K38/1709 ,  C12Q2600/158 ,  G01N2333/4706 ,  G01N2333/65 ,  G01N2333/70571 ,  G01N2500/00

摘要： The present invention is based on discovery of genes that are up- or down-regulated in inhibitory avoidance, e.g., long-term memory, which genes are therefor believed to have roles in memory consolidation. In particular, we have discovered that memory consolidation involves the regulation of expression of such genes as zif268 (EGR1), insulin-like growth factor (IGF-1), glutamate receptor (1 (GluR1), glutamate receptor 2 (GluR2), c/EBPβ and VGF. For ease of reading, these genes are collectively referred to herein as 'LTM genes', and their encoded proteins as 'LTM proteins'.

公开(公告)号：EP1161525A2

公开(公告)日：2001-12-12

申请号：EP00913904.9

申请日：2000-03-13

申请人： BROWN UNIVERSITY RESEARCH FOUNDATION

发明人： ALBERINI, Cristina, M. ,  BEAR, Mark, F. ,  COOPER, Leon, N. ,  TAUBENFELD, Stephen, M. ,  WIIG, Kjesten, A.

IPC分类号： C12N15/00 ,  A01K67/027 ,  A61K49/00 ,  A61P25/28 ,  A61K35/30

CPC分类号： C12Q1/6809 ,  A01K67/027

摘要： The present invention provides methods for identifying genes involved in memory consolidation, and for identifying agents which effect memory consolidation in a mammal. These methods preferably use (1) non-human mammals which have been manipulated to create at least partial disruption of fornix-mediated afferant signalling to the hippocampus, said disruption affecting memory consolidation or (2) non-lesioned mammals which have been subjected to a learning and memory test to provide a learned behavior in the mammal.