发明公开
- 专利标题: DNA CONSTRUCTS BASED ON THE EIF4A GENE PROMOTER
- 专利标题(中): ON THE AIF4A基因启动子的DNA构建体基于
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申请号: EP00942269.2申请日: 2000-07-05
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公开(公告)号: EP1190083A2公开(公告)日: 2002-03-27
- 发明人: GREAVES, David RobertSir William Dunn Sch. Path. , THOMSEN, Lindy , CATCHPOLE, Ian Richard , FORD, Martin James
- 申请人: GLAXO GROUP LIMITED
- 申请人地址: Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB
- 专利权人: GLAXO GROUP LIMITED
- 当前专利权人: GLAXO GROUP LIMITED
- 当前专利权人地址: Glaxo Wellcome HouseBerkeley Avenue Greenford, Middlesex UB6 ONN GB
- 代理机构: Dalton, Marcus Jonathan William
- 优先权: GB9915638 19990706; GB9929547 19991214
- 国际公布: WO0102594 20010111
- 主分类号: C12N15/85
- IPC分类号: C12N15/85 ; C12N15/12 ; C12N5/10 ; A61K31/17
摘要:
The present invention provides novel DNA constructs comprising a transcriptional regulatory sequence comprising a polynucleotide derivable from the eIF4A1 gene promoter. In preferred embodiments, the polynucleotide further comprises a polynucleotide derivable from the eIF4A gene introns, particularly intron 1. Host cells harbouring the constructs are also provided. These novel constructs have applications in gene therapy, DNA vaccines and in the commercial production of proteins.
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