发明公开
EP1229134A2 Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
审中-公开
识别核酸序列影响使用转录后基因沉默的其中的细胞的功能
- 专利标题： Use of post-transcriptional gene silencing for identifying nucleic acid sequences that modulate the function of a cell
- 专利标题（中）： 识别核酸序列影响使用转录后基因沉默的其中的细胞的功能
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申请号： EP02250681.0申请日： 2002-01-31
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公开(公告)号： EP1229134A2公开(公告)日： 2002-08-07
- 发明人: Giordano, Tony , Pachuk, Catherine , Satishchandran, Chandrasekhar
- 申请人： Nucleonics, Inc , Message Pharmaceuticals, Inc.
- 申请人地址： 36 Spring Mill Drive Malvern, Pennsylvania 19355 US
- 专利权人： Nucleonics, Inc,Message Pharmaceuticals, Inc.
- 当前专利权人： Nucleonics, Inc,Message Pharmaceuticals, Inc.
- 当前专利权人地址： 36 Spring Mill Drive Malvern, Pennsylvania 19355 US
- 代理机构： Davies, Jonathan Mark
- 优先权： US265805P 20010131; US339260P 20011026
- 主分类号： C12Q1/68
- IPC分类号： C12Q1/68 ; C12N15/10 ; G01N33/50
摘要：
Described herein are methods for identifying nucleic acid sequences that modulate the function of a cell, the expression of a gene in a cell, or the biological activity of a target polypeptide in a cell. The methods involve the use of double stranded RNA expression libraries, double stranded RNA molecules, and post-transcriptional gene silencing techniques.
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